Age of Drinking Initiation As a Risk Factor for Alcohol Use Disorder Symptoms is Moderated by ALDH2*2 and Ethnicity

Overview

Journal Alcohol Clin Exp Res

Specialty Psychiatry

Date 2017 Aug 29

PMID 28847041

Citations 6

Authors

Susan E Luczak

Tiebing Liang

Tamara L Wall

Affiliations

Soon will be listed here.

Abstract

Background: An early age of drinking initiation (ADI) has been associated with increased risk for alcohol use disorders (AUDs), but the consistency of this risk across diverse samples has not been well studied. The purpose of this study was to examine whether the pathway from ADI to AUD symptoms by early adulthood is moderated by ethnicity and possessing an alcohol-metabolizing gene ALDH2*2 variant allele.

Methods: We used multigroup structural equation modeling, including 5 groups split by ethnicity and ALDH2*2, to examine the consistency of the path from ADI to AUD symptoms in 604 Chinese-, Korean-, and White-American college students. We further examined the effects of ALDH2*2, ethnicity, and their interaction in Asians to better understand their unique contributions to the moderation.

Results: The association between ADI and AUD symptoms was moderated, with ADI negatively associated with AUD symptoms among Koreans without ALDH2*2 and Whites, but not among Koreans with ALDH2*2 or Chinese regardless of ALDH2*2. Both ALDH2*2 and ethnicity within Asians contributed unique variability in the effect.

Conclusions: Ethnicity and ALDH2*2 altered the relationship of ADI as a risk factor for AUD symptoms. Being Chinese and possessing an ALDH2*2 allele within Koreans both buffered against the risk for AUD symptoms associated with earlier ADI, indicating that this relationship can be attenuated by protective factors.

Citing Articles

Alcohol Consumption and Cardiovascular Disease: A Narrative Review of Evolving Perspectives and Long-Term Implications.

Georgescu O, Martin L, Tartea G, Rotaru-Zavaleanu A, Dinescu S, Vasile R Life (Basel). 2024; 14(9).

PMID: 39337917 PMC: 11433171. DOI: 10.3390/life14091134.

Associated and intermediate factors between genetic variants of the dopaminergic D2 receptor gene and harmful alcohol use in young adults.

Mattioni J, Vansteene C, Poupon D, Gorwood P, Ramoz N Addict Biol. 2023; 28(3):e13269.

PMID: 36825486 PMC: 10078472. DOI: 10.1111/adb.13269.

Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice.

Hu Q, Chen H, Shen C, Zhang B, Weng X, Sun X Alcohol Clin Exp Res. 2022; 46(5):707-723.

PMID: 35315077 PMC: 9321750. DOI: 10.1111/acer.14811.

Correlates of transitions from alcohol use to disorder diagnosed by DSM-5 in China.

Zhang T, Liu Z, Li G, Huang Y, Li Y, Geng H BMC Psychiatry. 2021; 21(1):427.

PMID: 34465307 PMC: 8406607. DOI: 10.1186/s12888-021-03413-w.

Acetaldehyde Enhances Alcohol Sensitivity and Protects against Alcoholism: Evidence from Alcohol Metabolism in Subjects with Variant Gene Allele.

Chen Y, Yang L, Lai C, Yin S Biomolecules. 2021; 11(8).

PMID: 34439848 PMC: 8391449. DOI: 10.3390/biom11081183.

References

Schuckit M, Smith T, Anderson K, Brown S . Testing the level of response to alcohol: social information processing model of alcoholism risk--a 20-year prospective study. Alcohol Clin Exp Res. 2004; 28(12):1881-9. DOI: 10.1097/01.alc.0000148111.43332.a5. View

Hendershot C, MacPherson L, Myers M, Carr L, Wall T . Psychosocial, cultural and genetic influences on alcohol use in Asian American youth. J Stud Alcohol. 2005; 66(2):185-95. PMC: 2749922. DOI: 10.15288/jsa.2005.66.185. View

Luczak S, Pandika D, Shea S, Eng M, Liang T, Wall T . ALDH2 and ADH1B interactions in retrospective reports of low-dose reactions and initial sensitivity to alcohol in Asian American college students. Alcohol Clin Exp Res. 2011; 35(7):1238-45. PMC: 3116988. DOI: 10.1111/j.1530-0277.2011.01458.x. View

Grant B, Dawson D . Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse. 1997; 9:103-10. DOI: 10.1016/s0899-3289(97)90009-2. View

Cloninger C . Neurogenetic adaptive mechanisms in alcoholism. Science. 1987; 236(4800):410-6. DOI: 10.1126/science.2882604. View

Luczak S, Wall T, Shea S, Byun S, CARR L . Binge drinking in Chinese, Korean, and White college students: genetic and ethnic group differences. Psychol Addict Behav. 2002; 15(4):306-9. DOI: 10.1037//0893-164x.15.4.306. View

Babor T, Hofmann M, DelBoca F, Hesselbrock V, Meyer R, Dolinsky Z . Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry. 1992; 49(8):599-608. DOI: 10.1001/archpsyc.1992.01820080007002. View

Clark T, Doyle O, Clincy A . Age of first cigarette, alcohol, and marijuana use among U.S. biracial/ethnic youth: a population-based study. Addict Behav. 2013; 38(9):2450-4. PMC: 4063551. DOI: 10.1016/j.addbeh.2013.04.005. View

King K, Chassin L . A prospective study of the effects of age of initiation of alcohol and drug use on young adult substance dependence. J Stud Alcohol Drugs. 2007; 68(2):256-65. DOI: 10.15288/jsad.2007.68.256. View

10.

Sartor C, Lynskey M, Heath A, Jacob T, True W . The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence. Addiction. 2007; 102(2):216-25. DOI: 10.1111/j.1360-0443.2006.01661.x. View

11.

Fowler T, Lifford K, Shelton K, Rice F, Thapar A, Neale M . Exploring the relationship between genetic and environmental influences on initiation and progression of substance use. Addiction. 2007; 102(3):413-22. PMC: 1974769. DOI: 10.1111/j.1360-0443.2006.01694.x. View

12.

YORK J . Clinical significance of alcohol intake parameters at initiation of drinking. Alcohol. 1999; 19(1):97-9. DOI: 10.1016/s0741-8329(99)00020-8. View

13.

McGue M, Iacono W, Legrand L, Malone S, Elkins I . Origins and consequences of age at first drink. I. Associations with substance-use disorders, disinhibitory behavior and psychopathology, and P3 amplitude. Alcohol Clin Exp Res. 2001; 25(8):1156-65. View

14.

Luczak S, Glatt S, Wall T . Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians. Psychol Bull. 2006; 132(4):607-21. DOI: 10.1037/0033-2909.132.4.607. View

15.

Bucholz K, CADORET R, Cloninger C, Dinwiddie S, Hesselbrock V, Nurnberger Jr J . A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol. 1994; 55(2):149-58. DOI: 10.15288/jsa.1994.55.149. View

16.

Donovan J, JESSOR R . Structure of problem behavior in adolescence and young adulthood. J Consult Clin Psychol. 1985; 53(6):890-904. DOI: 10.1037//0022-006x.53.6.890. View

17.

Dewit D, Adlaf E, Offord D, Ogborne A . Age at first alcohol use: a risk factor for the development of alcohol disorders. Am J Psychiatry. 2000; 157(5):745-50. DOI: 10.1176/appi.ajp.157.5.745. View

18.

Pedersen W, Skrondal A . Alcohol consumption debut: predictors and consequences. J Stud Alcohol. 1998; 59(1):32-42. DOI: 10.15288/jsa.1998.59.32. View

19.

Kane J, Damian A, Fairman B, Bass J, Iwamoto D, Johnson R . Differences in alcohol use patterns between adolescent Asian American ethnic groups: Representative estimates from the National Survey on Drug Use and Health 2002-2013. Addict Behav. 2016; 64:154-158. PMC: 5143158. DOI: 10.1016/j.addbeh.2016.08.045. View

20.

Dawson D, Goldstein R, Chou S, Ruan W, Grant B . Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders. Alcohol Clin Exp Res. 2008; 32(12):2149-60. PMC: 2760820. DOI: 10.1111/j.1530-0277.2008.00806.x. View