The Improvement of Skin Whitening of Phenylethyl Resorcinol by Nanostructured Lipid Carriers

Overview

Journal Nanomaterials (Basel)

Date 2017 Aug 29

PMID 28846658

Citations 10

Authors

Bo-Sik Kim

Young-Guk Na

Jae-Hwan Choi

Inhye Kim

Eunji Lee

Sung-Yeon Kim

Jae-Young Lee

Cheong-Weon Cho

Affiliations

Soon will be listed here.

Abstract

Phenylethyl resorcinol (4-(1-phenylethyl)1,3-benzenediol) (PR) is a new whitening agent that has been found to have the ability to inhibit tyrosinase activity. However, the application of PR is limited by photo instability and poor solubility. PR-loaded nanostructured lipid carriers (PR-NLCs) were prepared by the hot-melted ultrasonic method. Glycerol monostearate and olive oil were selected as the solid lipid and liquid lipid for considering the solubility of PR in liquid lipid and partition coefficient of PR in solid lipid, respectively. The particle size and polydispersity index of PR-NLCs were 57.9 ± 1.3 nm and 0.24 ± 0.01, respectively. The encapsulation efficiency and loading capacity of PR-NLCs were 93.1 ± 4.2% and 8.5 ± 0.4%, respectively. The stability test demonstrated that the incorporation of PR into NLCs conferred excellent physicochemical stability and photo stability for at least three months at 4 °C in the dark and 25 °C under daylight. In vitro release of PR-NLCs revealed a sustained release pattern. Cellular tyrosinase assay showed that PR-NLCs could significantly inhibit tyrosinase activity in melanoma cells, suggesting that NLCs can be used as a biocompatible nanocarrier for the effective delivery of skin whitening agents.

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References

Zhuang C, Li N, Wang M, Zhang X, Pan W, Peng J . Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability. Int J Pharm. 2010; 394(1-2):179-85. DOI: 10.1016/j.ijpharm.2010.05.005. View

Patel K, Padhye S, Nagarsenker M . Duloxetine HCl lipid nanoparticles: preparation, characterization, and dosage form design. AAPS PharmSciTech. 2011; 13(1):125-33. PMC: 3299448. DOI: 10.1208/s12249-011-9727-6. View

Patil-Gadhe A, Pokharkar V . Montelukast-loaded nanostructured lipid carriers: part I oral bioavailability improvement. Eur J Pharm Biopharm. 2014; 88(1):160-8. DOI: 10.1016/j.ejpb.2014.05.019. View

Jia L, Shen J, Zhang D, Duan C, Liu G, Zheng D . In vitro and in vivo evaluation of oridonin-loaded long circulating nanostructured lipid carriers. Int J Biol Macromol. 2012; 50(3):523-9. DOI: 10.1016/j.ijbiomac.2012.01.024. View

ODriscoll C, Griffin B . Biopharmaceutical challenges associated with drugs with low aqueous solubility--the potential impact of lipid-based formulations. Adv Drug Deliv Rev. 2007; 60(6):617-24. DOI: 10.1016/j.addr.2007.10.012. View

Mehnert W, Mader K . Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev. 2001; 47(2-3):165-96. DOI: 10.1016/s0169-409x(01)00105-3. View

Sangsen Y, Wiwattanawongsa K, Likhitwitayawuid K, Sritularak B, Wiwattanapatapee R . Modification of oral absorption of oxyresveratrol using lipid based nanoparticles. Colloids Surf B Biointerfaces. 2015; 131:182-90. DOI: 10.1016/j.colsurfb.2015.04.055. View

Pastor-Nieto M, Sanchez-Pedreno P, Martinez-Menchon T, Melgar-Molero V, Alcantara-Nicolas F, de la Cruz-Murie P . Allergic contact dermatitis caused by phenylethyl resorcinol, a skin-lightening agent contained in a sunscreen. Contact Dermatitis. 2016; 75(4):250-3. DOI: 10.1111/cod.12617. View

Hunt G, Todd C, Cresswell J, Thody A . Alpha-melanocyte stimulating hormone and its analogue Nle4DPhe7 alpha-MSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes. J Cell Sci. 1994; 107 ( Pt 1):205-11. DOI: 10.1242/jcs.107.1.205. View

10.

Baek J, Pham C, Myung C, Cho C . Tadalafil-loaded nanostructured lipid carriers using permeation enhancers. Int J Pharm. 2015; 495(2):701-9. DOI: 10.1016/j.ijpharm.2015.09.054. View

11.

Venkateswarlu V, Manjunath K . Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. J Control Release. 2004; 95(3):627-38. DOI: 10.1016/j.jconrel.2004.01.005. View

12.

Kyadarkunte A, Patole M, Pokharkar V . Cellular interactions and photoprotective effects of idebenone-loaded nanostructured lipid carriers stabilized using PEG-free surfactant. Int J Pharm. 2014; 479(1):77-87. DOI: 10.1016/j.ijpharm.2014.12.044. View

13.

Liu Y, Wang L, Zhao Y, He M, Zhang X, Niu M . Nanostructured lipid carriers versus microemulsions for delivery of the poorly water-soluble drug luteolin. Int J Pharm. 2014; 476(1-2):169-77. DOI: 10.1016/j.ijpharm.2014.09.052. View

14.

Shete H, Patravale V . Long chain lipid based tamoxifen NLC. Part I: preformulation studies, formulation development and physicochemical characterization. Int J Pharm. 2013; 454(1):573-83. DOI: 10.1016/j.ijpharm.2013.03.034. View

15.

Schmaus G, Vielhaber G, Jacobs K, Franke H . 4-(1-Phenylethyl) 1,3-benzenediol: a new highly potent lightening agent. J Cosmet Sci. 2006; 57(2):197-8. View

16.

Wosicka-Frackowiak H, Cal K, Stefanowska J, Glowka E, Nowacka M, Struck-Lewicka W . Roxithromycin-loaded lipid nanoparticles for follicular targeting. Int J Pharm. 2015; 495(2):807-15. DOI: 10.1016/j.ijpharm.2015.09.068. View

17.

How C, Rasedee A, Manickam S, Rosli R . Tamoxifen-loaded nanostructured lipid carrier as a drug delivery system: characterization, stability assessment and cytotoxicity. Colloids Surf B Biointerfaces. 2013; 112:393-9. DOI: 10.1016/j.colsurfb.2013.08.009. View

18.

Meng Lim W, Rajinikanth P, Mallikarjun C, Kang Y . Formulation and delivery of itraconazole to the brain using a nanolipid carrier system. Int J Nanomedicine. 2014; 9:2117-26. PMC: 4014385. DOI: 10.2147/IJN.S57565. View

19.

Zhang W, Liu J, Zhang Q, Li X, Yu S, Yang X . Enhanced cellular uptake and anti-proliferating effect of chitosan hydrochlorides modified genistein loaded NLC on human lens epithelial cells. Int J Pharm. 2014; 471(1-2):118-26. DOI: 10.1016/j.ijpharm.2014.05.030. View

20.

Kumar S, Randhawa J . Preparation and characterization of Paliperidone loaded solid lipid nanoparticles. Colloids Surf B Biointerfaces. 2012; 102:562-8. DOI: 10.1016/j.colsurfb.2012.08.052. View