Radiolabeled Dendrimers for Nuclear Medicine Applications

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2017 Aug 26

PMID 28841180

Citations 10

Authors

Lingzhou Zhao

MeiLin Zhu

Yujie Li

Yan Xing

Jinhua Zhao

Affiliations

Soon will be listed here.

Abstract

Recent advances in nuclear medicine have explored nanoscale carriers for targeted delivery of various radionuclides in specific manners to improve the effect of diagnosis and therapy of diseases. Due to the unique molecular architecture allowing facile attachment of targeting ligands and radionuclides, dendrimers provide versatile platforms in this filed to build abundant multifunctional radiolabeled nanoparticles for nuclear medicine applications. This review gives special focus to recent advances in dendrimer-based nuclear medicine agents for the imaging and treatment of cancer, cardiovascular and other diseases. Radiolabeling strategies for different radionuclides and several challenges involved in clinical translation of radiolabeled dendrimers are extensively discussed.

Citing Articles

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