Ginseng Extract G115 Attenuates Ethanol-Induced Depression in Mice by Increasing Brain BDNF Levels

Overview

Journal Nutrients

Date 2017 Aug 25

PMID 28837087

Citations 14

Authors

Weerawan Boonlert

Hattaya Benya-Aphikul

Jariya Umka Welbat

Ratchanee Rodsiri

Affiliations

Soon will be listed here.

Abstract

The decrease of brain-derived neurotrophic factor (BDNF) has been reported in alcohol use disorder and major depression. The effective treatment of these comorbid diseases remains undiscovered. Nutraceutical products are therefore proposed as an alternative approach to overcome this challenge. Ginseng extract G115, the standardized extract of , is a widely-used nutraceutical that is beneficial for various central nervous system disorders. This study aimed to determine the antidepressant effect of ginseng extract G115 in ethanol-treated mice models. Mice received either water, amitriptyline, or various doses of G115 (p.o.) followed by water or ethanol (i.p.) for 8 days. The antidepressant activity was evaluated using forced swimming test. BDNF levels were measured from hippocampal and prefrontal cortex tissues. The results demonstrated that the increase of immobility time in depressant mice induced by ethanol was reversed by both G115 and amitriptyline treatment. A significant increase of BDNF levels in the hippocampus and prefrontal cortex was observed in ethanol-treated mice receiving G115. Taken together, this study provides scientific information on the use of G115 as an antidepressant that could be further used as a dietary supplement in comorbid alcohol use and major depressive disorders.

Citing Articles

Combining Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Total Ginsenoside Ginseng Root and Its Impact on Antidepressant Effects.

Chen W, Guo P, Su L, Guo X, Shi M, Geng J Int J Mol Sci. 2024; 25(23).

PMID: 39684318 PMC: 11640795. DOI: 10.3390/ijms252312606.

Protective effect of ginseng extract and total ginsenosides on hematopoietic stem cell damage by inhibiting cell apoptosis and regulating the intestinal microflora.

Liang Z, Gao X, Jing C, Yuan T, Zhang L, Yin Y Int J Mol Med. 2024; 55(1).

PMID: 39513620 PMC: 11573321. DOI: 10.3892/ijmm.2024.5455.

Neurotrophic Natural Products.

Fukuyama Y, Kubo M, Harada K Prog Chem Org Nat Prod. 2024; 123:1-473.

PMID: 38340248 DOI: 10.1007/978-3-031-42422-9_1.

Phycocyanin alleviates alcohol-induced testicular injury in male Wistar rats.

Boukari O, Ghoghbane S, Khemissi W, Lassili T, Tebourbi O, Ben Rhouma K Clin Exp Reprod Med. 2024; 51(2):102-111.

PMID: 38229438 PMC: 11140253. DOI: 10.5653/cerm.2023.06422.

Inhalation of panaxadiol alleviates lung inflammation inhibiting TNFA/TNFAR and IL7/IL7R signaling between macrophages and epithelial cells.

Wang Y, Wei H, Song Z, Jiang L, Zhang M, Lu X J Ginseng Res. 2024; 48(1):77-88.

PMID: 38223829 PMC: 10785239. DOI: 10.1016/j.jgr.2023.09.002.

References

Yu H, Chen Z . The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacol Sin. 2010; 32(1):3-11. PMC: 4003317. DOI: 10.1038/aps.2010.184. View

Castren E, Rantamaki T . The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity. Dev Neurobiol. 2010; 70(5):289-97. DOI: 10.1002/dneu.20758. View

Briones T, Woods J . Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis. Neuroscience. 2013; 254:324-34. PMC: 3983287. DOI: 10.1016/j.neuroscience.2013.09.031. View

Mizui T, Ishikawa Y, Kumanogoh H, Kojima M . Neurobiological actions by three distinct subtypes of brain-derived neurotrophic factor: Multi-ligand model of growth factor signaling. Pharmacol Res. 2016; 105:93-8. DOI: 10.1016/j.phrs.2015.12.019. View

Litten R, Fertig J, Mattson M, Egli M . Development of medications for alcohol use disorders: recent advances and ongoing challenges. Expert Opin Emerg Drugs. 2005; 10(2):323-43. DOI: 10.1517/14728214.10.2.323. View

Sairanen M, OLeary O, Knuuttila J, Castren E . Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat. Neuroscience. 2006; 144(1):368-74. DOI: 10.1016/j.neuroscience.2006.08.069. View

Dang H, Chen Y, Liu X, Wang Q, Wang L, Jia W . Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2009; 33(8):1417-24. DOI: 10.1016/j.pnpbp.2009.07.020. View

Lyons L, Elbeltagy M, Umka J, Markwick R, Startin C, Bennett G . Fluoxetine reverses the memory impairment and reduction in proliferation and survival of hippocampal cells caused by methotrexate chemotherapy. Psychopharmacology (Berl). 2010; 215(1):105-15. PMC: 3072503. DOI: 10.1007/s00213-010-2122-2. View

Graham K, Massak A, Demers A, Rehm J . Does the association between alcohol consumption and depression depend on how they are measured?. Alcohol Clin Exp Res. 2007; 31(1):78-88. DOI: 10.1111/j.1530-0277.2006.00274.x. View

10.

Reus G, Dos Santos M, Abelaira H, Ribeiro K, Petronilho F, Vuolo F . Imipramine reverses alterations in cytokines and BDNF levels induced by maternal deprivation in adult rats. Behav Brain Res. 2012; 242:40-6. DOI: 10.1016/j.bbr.2012.11.044. View

11.

Petrakis I, Ralevski E, Nich C, Levinson C, Carroll K, Poling J . Naltrexone and disulfiram in patients with alcohol dependence and current depression. J Clin Psychopharmacol. 2007; 27(2):160-5. DOI: 10.1097/jcp.0b13e3180337fcb. View

12.

Pettinati H . Antidepressant treatment of co-occurring depression and alcohol dependence. Biol Psychiatry. 2004; 56(10):785-92. DOI: 10.1016/j.biopsych.2004.07.016. View

13.

Kozisek M, Middlemas D, Bylund D . The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment. Neuropharmacology. 2007; 54(2):251-7. DOI: 10.1016/j.neuropharm.2007.08.001. View

14.

Getachew B, Hauser S, Taylor R, Tizabi Y . Alcohol-induced depressive-like behavior is associated with cortical norepinephrine reduction. Pharmacol Biochem Behav. 2010; 96(4):395-401. PMC: 2967716. DOI: 10.1016/j.pbb.2010.06.011. View

15.

Yang Y, Zhang Z, Li S, Ye X, Li X, He K . Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis. Fitoterapia. 2013; 92:133-47. DOI: 10.1016/j.fitote.2013.10.010. View

16.

Umka J, Mustafa S, Elbeltagy M, Thorpe A, Latif L, Bennett G . Valproic acid reduces spatial working memory and cell proliferation in the hippocampus. Neuroscience. 2009; 166(1):15-22. DOI: 10.1016/j.neuroscience.2009.11.073. View

17.

Xu C, Teng J, Chen W, Ge Q, Yang Z, Yu C . 20(S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests. Prog Neuropsychopharmacol Biol Psychiatry. 2010; 34(8):1402-11. DOI: 10.1016/j.pnpbp.2010.07.010. View

18.

Autry A, Monteggia L . Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev. 2012; 64(2):238-58. PMC: 3310485. DOI: 10.1124/pr.111.005108. View

19.

Liu X, Zhou X, Hou J, Zhu H, Wang Z, Liu J . Ginsenoside Rd promotes neurogenesis in rat brain after transient focal cerebral ischemia via activation of PI3K/Akt pathway. Acta Pharmacol Sin. 2015; 36(4):421-8. PMC: 4387301. DOI: 10.1038/aps.2014.156. View

20.

Chen L, Dai J, Wang Z, Zhang H, Huang Y, Zhao Y . The antidepressant effects of ginseng total saponins in male C57BL/6N mice by enhancing hippocampal inhibitory phosphorylation of GSK-3β. Phytother Res. 2014; 28(7):1102-6. DOI: 10.1002/ptr.5103. View