The Role of the Leukemia Inhibitory Factor Receptor in Neuroprotective Signaling

Overview

Journal Pharmacol Ther

Specialty Pharmacology

Date 2017 Aug 23

PMID 28827150

Citations 27

Authors

Stephanie M Davis

Keith R Pennypacker

Affiliations

Soon will be listed here.

Abstract

Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190kDa subunit couples with the 130kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison. This review examines the role of this receptor in the CNS and immune system, and its application in the treatment in stroke and other brain pathologies.

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