A 38-year-old Woman with Necrotising Cervical Lymphadenitis Due to Histoplasma Capsulatum

Overview

Journal Infection

Date 2017 Aug 20

PMID 28822097

Citations 12

Authors

Esther van de Vosse

Annelies van Wengen

Wendy F van der Meide

Leo G Visser

Jaap T van Dissel

Affiliations

Soon will be listed here.

Abstract

Case Presentation: We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum.

Conclusion: IFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies.

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