Galangin, a Natural Flavonoid Reduces Mitochondrial Oxidative Damage in Streptozotocin-induced Diabetic Rats

Overview

Journal Redox Rep

Specialties Biochemistry
Biology
Endocrinology

Date 2017 Aug 17

PMID 28813209

Citations 13

Authors

Amal A Aloud

Chinnadurai Veeramani

Chandramohan Govindasamy

Mohammed A Alsaif

Khalid S Al-Numair

Affiliations

Soon will be listed here.

Abstract

Objective: We designed this study to observe the effect of galangin on damaged mitochondria in the liver of diabetic rats.

Methods: Male albino Wistar rats were made diabetic by injecting streptozotocin (STZ) intraperitoneally (40 mg kg body weight (BW)). Galangin (8 mg kg BW) or glibenclamide (600 µg kg BW) was given orally daily once for 45 days to both healthy and diabetic rats.

Results: Diabetic rats showed significant (P < 0.05) increase in liver mitochondrial oxidant [Thiobarbituric acid reactive substance (TBARS)] level and a significant decrease in enzymatic [superoxide dismutase (SOD), glutathione peroxidase (GPx)] and non-enzymatic (reduced glutathione (GSH)) antioxidant levels when compared with healthy rats. The mitochondrial enzymes isocitrate dehydrogenase (ICDH), alpha-ketoglutarate dehydrogenase (α-KGDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH) and mitochondrial respiratory chain enzymes NADH-dehydrogenase and Cytochrome c-oxidase were decreased significantly (P < 0.05) in diabetic rats when compared with healthy rats. A natural flavonoid galangin administered to hyperglycemia-induced rats resulted in the following findings as compared to hyperglycemia-induced control rats: the oxidant levels decreased significantly (P < 0.05); the enzymatic and non-enzymatic antioxidant levels increased significantly (P < 0.05) and the function of mitochondrial enzymes and the mitochondrial respiratory chain enzymes increased significantly (P < 0.05).

Conclusion: From the results, we conclude that galangin could maintain liver mitochondrial function in diabetic rats.

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