The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2017 Aug 17

PMID 28812256

Citations 9

Authors

Ayse Bilge Ozturk

Benjamin Arthur Turturice

David L Perkins

Patricia W Finn

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: In terms of immune regulating functions, analysis of the microbiome has led the development of therapeutic strategies that may be applicable to asthma management. This review summarizes the current literature on the gut and lung microbiota in asthma pathogenesis with a focus on the roles of innate molecules and new microbiome-mediated therapeutics.

Recent Findings: Recent clinical and basic studies to date have identified several possible therapeutics that can target innate immunity and the microbiota in asthma. Some of these drugs have shown beneficial effects in the treatment of certain asthma phenotypes and for protection against asthma during early life. Current clinical evidence does not support the use of these therapies for effective treatment of asthma. The integration of the data regarding microbiota with technologic advances, such as next generation sequencing and omics offers promise. Combining comprehensive bioinformatics, new molecules and approaches may shape future asthma treatment.

Citing Articles

Gut-lung axis and asthma: A historical review on mechanism and future perspective.

Song X, Liang J, Lin S, Xie Y, Ke C, Ao D Clin Transl Allergy. 2024; 14(5):e12356.

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Novel potential treatable traits in asthma: Where is the research taking us?.

Carr T, Peters M J Allergy Clin Immunol Glob. 2023; 1(2):27-36.

PMID: 37780590 PMC: 10509971. DOI: 10.1016/j.jacig.2022.04.001.

The Role of the Microbiome in the Pathogenesis and Treatment of Asthma.

Logon K, Swirkosz G, Nowak M, Wrzesniewska M, Szczygiel A, Gomulka K Biomedicines. 2023; 11(6).

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Microbiota - The Unseen Players in Adult Asthmatic Airways.

Ozturk A, Ranjan R, Rani A, Yazici D, Bavbek S Turk Thorac J. 2021; 22(1):75-82.

PMID: 33646108 PMC: 7919442. DOI: 10.5152/TurkThoracJ.2020.19085.

The short-chain free fatty acid receptor FFAR3 is expressed and potentiates contraction in human airway smooth muscle.

Mizuta K, Sasaki H, Zhang Y, Matoba A, Emala Sr C Am J Physiol Lung Cell Mol Physiol. 2020; 318(6):L1248-L1260.

PMID: 32209026 PMC: 7347267. DOI: 10.1152/ajplung.00357.2019.

References

Riedler J, Braun-Fahrlander C, Eder W, Schreuer M, Waser M, Maisch S . Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet. 2001; 358(9288):1129-33. DOI: 10.1016/S0140-6736(01)06252-3. View

Wu G, Chen J, Hoffmann C, Bittinger K, Chen Y, Keilbaugh S . Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011; 334(6052):105-8. PMC: 3368382. DOI: 10.1126/science.1208344. View

Bengmark S, Martindale R . Prebiotics and synbiotics in clinical medicine. Nutr Clin Pract. 2005; 20(2):244-61. DOI: 10.1177/0115426505020002244. View

Asada M, Yoshida M, Suzuki T, Hatachi Y, Sasaki T, Yasuda H . Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells. Antiviral Res. 2009; 83(2):191-200. DOI: 10.1016/j.antiviral.2009.05.003. View

Paturi G, Butts C, Monro J, Nones K, Martell S, Butler R . Cecal and colonic responses in rats fed 5 or 30% corn oil diets containing either 7.5% broccoli dietary fiber or microcrystalline cellulose. J Agric Food Chem. 2010; 58(10):6510-5. DOI: 10.1021/jf100296m. View

Daniel C, Repa A, Wild C, Pollak A, Pot B, Breiteneder H . Modulation of allergic immune responses by mucosal application of recombinant lactic acid bacteria producing the major birch pollen allergen Bet v 1. Allergy. 2006; 61(7):812-9. DOI: 10.1111/j.1398-9995.2006.01071.x. View

Kim Y, Park C, Lim D, Ahn S, Son B, Kim J . Beneficial effect of anti-interleukin-33 on the murine model of allergic inflammation of the lower airway. J Asthma. 2012; 49(7):738-43. DOI: 10.3109/02770903.2012.702841. View

Nabe T . Interleukin (IL)-33: new therapeutic target for atopic diseases. J Pharmacol Sci. 2014; 126(2):85-91. DOI: 10.1254/jphs.14r12cp. View

Rosas-Salazar C, Shilts M, Tovchigrechko A, Chappell J, Larkin E, Nelson K . Nasopharyngeal Microbiome in Respiratory Syncytial Virus Resembles Profile Associated with Increased Childhood Asthma Risk. Am J Respir Crit Care Med. 2016; 193(10):1180-3. PMC: 4872668. DOI: 10.1164/rccm.201512-2350LE. View

10.

Slater M, Rivett D, Williams L, Martin M, Harrison T, Sayers I . The impact of azithromycin therapy on the airway microbiota in asthma. Thorax. 2013; 69(7):673-4. PMC: 4078717. DOI: 10.1136/thoraxjnl-2013-204517. View

11.

Kostadima E, Tsiodras S, Alexopoulos E, Kaditis A, Mavrou I, Georgatou N . Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma. Eur Respir J. 2004; 23(5):714-7. DOI: 10.1183/09031936.04.00118404. View

12.

Ci X, Chu X, Xu X, Li H, Deng X . Short-term roxithromycin treatment attenuates airway inflammation via MAPK/NF-κB activation in a mouse model of allergic asthma. Inflamm Res. 2012; 61(7):749-58. DOI: 10.1007/s00011-012-0470-6. View

13.

Rajilic-Stojanovic M, Smidt H, de Vos W . Diversity of the human gastrointestinal tract microbiota revisited. Environ Microbiol. 2007; 9(9):2125-36. DOI: 10.1111/j.1462-2920.2007.01369.x. View

14.

Teo S, Mok D, Pham K, Kusel M, Serralha M, Troy N . The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development. Cell Host Microbe. 2015; 17(5):704-15. PMC: 4433433. DOI: 10.1016/j.chom.2015.03.008. View

15.

Lee H, Rhee C, Kang J, Byun J, Choi J, Kim S . Blockade of IL-33/ST2 ameliorates airway inflammation in a murine model of allergic asthma. Exp Lung Res. 2014; 40(2):66-76. DOI: 10.3109/01902148.2013.870261. View

16.

Peabody M, Van Rossum T, Lo R, Brinkman F . Evaluation of shotgun metagenomics sequence classification methods using in silico and in vitro simulated communities. BMC Bioinformatics. 2015; 16:363. PMC: 4634789. DOI: 10.1186/s12859-015-0788-5. View

17.

Shikotra A, Choy D, Ohri C, Doran E, Butler C, Hargadon B . Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma. J Allergy Clin Immunol. 2011; 129(1):104-11.e1-9. DOI: 10.1016/j.jaci.2011.08.031. View

18.

Casale T, Kessler J, Romero F . Safety of the intranasal toll-like receptor 4 agonist CRX-675 in allergic rhinitis. Ann Allergy Asthma Immunol. 2006; 97(4):454-6. DOI: 10.1016/S1081-1206(10)60934-9. View

19.

. Structure, function and diversity of the healthy human microbiome. Nature. 2012; 486(7402):207-14. PMC: 3564958. DOI: 10.1038/nature11234. View

20.

Ellwood P, Asher M, Garcia-Marcos L, Williams H, Keil U, Robertson C . Do fast foods cause asthma, rhinoconjunctivitis and eczema? Global findings from the International Study of Asthma and Allergies in Childhood (ISAAC) phase three. Thorax. 2013; 68(4):351-60. DOI: 10.1136/thoraxjnl-2012-202285. View