FEV and FVC and Systemic Inflammation in a Spinal Cord Injury Cohort

Overview

Journal BMC Pulm Med

Publisher Biomed Central

Specialty Pulmonary Medicine

Date 2017 Aug 17

PMID 28810847

Citations 9

Authors

Jaime E Hart

Rebekah Goldstein

Palak Walia

Merilee Teylan

Antonio Lazzari

Carlos G Tun

Eric Garshick

Affiliations

Soon will be listed here.

Abstract

Background: Systemic inflammation has been associated with reduced pulmonary function in individuals with and without chronic medical conditions. Individuals with chronic spinal cord injury (SCI) have clinical characteristics that promote systemic inflammation and also have reduced pulmonary function. We sought to assess the associations between biomarkers of systemic inflammation with pulmonary function in a chronic SCI cohort, adjusting for other potential confounding factors.

Methods: Participants (n = 311) provided a blood sample, completed a respiratory health questionnaire, and underwent spirometry. Linear regression methods were used to assess cross-sectional associations between plasma C-reactive protein (CRP) and interleukin-6 (IL-6) with forced expiratory volume in one second (FEV), forced vital capacity (FVC), and FEV/FVC.

Results: There were statistically significant inverse relationships between plasma CRP and IL-6 assessed in quartiles or continuously with FEV and FVC. In fully adjusted models, each interquartile range (5.91 mg/L) increase in CRP was associated with a significant decrease in FEV (-55.85 ml; 95% CI: -89.21, -22.49) and decrease in FVC (-65.50 ml; 95% CI: -106.61, -24.60). There were similar significant findings for IL-6. There were no statistically significant associations observed with FEV/FVC.

Conclusion: Plasma CRP and IL-6 in individuals with chronic SCI are inversely associated with FEV and FVC, independent of SCI level and severity of injury, BMI, and other covariates. This finding suggests that systemic inflammation associated with chronic SCI may contribute to reduced pulmonary function.

Citing Articles

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Tsai C, Li H, Yang W, Jhan Y Spinal Cord Ser Cases. 2024; 10(1):27.

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Alostaz H, Cai L Curr Pharmacol Rep. 2022; 8(1):20-30.

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Xiang X, Zong H, Ou Y, Yu X, Cheng H, Du C J Neuroeng Rehabil. 2021; 18(1):86.

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