USP3 Stabilizes P53 Protein Through Its Deubiquitinase Activity

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 2017 Aug 16

PMID 28807825

Citations 16

Authors

Song Fu

Shize Shao

Longqiang Wang

Haijun Liu

Haitao Hou

Yanan Wang

Huan Wang

Xiangpeng Huang

Renhua Lv

Affiliations

Soon will be listed here.

Abstract

p53 is the guardian of the genome integrity and the degradation of p53 protein is mediated by MDM2. Here we report that USP3 interacts with p53 and regulates p53 stability. Depletion of USP3 lead to accelerated degradation of p53 in normal cells thereby enhanced cell proliferation and transformation. Reconstitution of wildtype USP3, but not the USP3 C168S mutant, restored the stability of p53 protein and inhibited cell proliferation and transformation. These findings suggest that USP3 is an important regulator of p53 and regulates normal cell transformation.

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