Circulating MicroRNAs in Malaria Infection: Bench to Bedside

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2017 Aug 16

PMID 28807026

Citations 21

Authors

Supat Chamnanchanunt

Suthat Fucharoen

Tsukuru Umemura

Affiliations

Soon will be listed here.

Abstract

Severe malaria has a poor prognosis with a morbidity rate of 80% in tropical areas. The early parasite detection is one of the effective means to prevent severe malaria of which specific treatment strategies are limited. Many clinical characteristics and laboratory testings have been used for the early diagnosis and prediction of severe disease. However, a few of these factors could be applied to clinical practice. MicroRNAs (miRNAs) were demonstrated as useful biomarkers in many diseases such as malignant diseases and cardiovascular diseases. Recently it was found that plasma miR-451 and miR-16 were downregulated in malaria infection at parasitic stages or with multi-organ failure involvement. MiR-125b, -27a, -23a, -150, 17-92 and -24 are deregulated in malaria patients with multiple organ failures. Here, the current findings of miRNAs were reviewed in relation to clinical severity of malaria infection and emphasized that miRNAs are potential biomarkers for severe malaria infection.

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