Vitamin D and Osteosarcopenia: an Update from Epidemiological Studies

Overview

Journal Curr Opin Clin Nutr Metab Care

Specialty General Medicine

Date 2017 Aug 15

PMID 28806178

Citations 13

Authors

Olivier Bruyere

Etienne Cavalier

Jean-Yves Reginster

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The review summarizes recent epidemiological studies that examined the relationship between osteoporosis and sarcopenia to assess the impact of vitamin D status or supplementation on health outcomes related to these two medical conditions.

Recent Findings: Osteoporosis and sarcopenia are major public health problems, but whether these two diseases should be considered alone or combined into a single condition is not clear. No consensual definition of osteosarcopenia is largely accepted. Most observational studies demonstrate some relationship between muscle and bone health. Vitamin D status is generally lower in study participants with bone or muscle wasting. Studies on the effects of vitamin D supplementation on muscle or bone health have provided conflicting results, likely because of the heterogeneity between studies. However, the most positive results were observed in study participants with low vitamin D status and in studies that avoided massive boluses of vitamin D.

Summary: More observational and interventional studies are needed to confirm the exact role of vitamin D in the pathophysiology and treatment of osteosarcopenia.

Citing Articles

Impact of Vitamin D Status and Nutrition on the Occurrence of Long Bone Fractures Due to Falls in Elderly Subjects in the Vojvodina Region of Serbia.

Gvozdenovic N, Sarac I, Coric A, Karan S, Nikolic S, Zdrale I Nutrients. 2024; 16(16).

PMID: 39203838 PMC: 11356805. DOI: 10.3390/nu16162702.

Vitamin D: Can Gender Medicine Have a Role?.

Ciarambino T, Crispino P, Minervini G, Giordano M Biomedicines. 2023; 11(6).

PMID: 37371857 PMC: 10296422. DOI: 10.3390/biomedicines11061762.

Very Low and High Levels of Vitamin D Are Associated with Shorter Leukocyte Telomere Length in 148,321 UK Biobank Participants.

Kuo C, Kirk B, Xiang M, Pilling L, Kuchel G, Kremer R Nutrients. 2023; 15(6).

PMID: 36986204 PMC: 10059691. DOI: 10.3390/nu15061474.

The Function of Body Mass Index in the Older with Osteosarcopenia: A Systematic Review and Meta-analysis.

Du Y, Tao S, Oh C, No J J Obes Metab Syndr. 2023; 32(1):77-86.

PMID: 36894327 PMC: 10088551. DOI: 10.7570/jomes22057.

Sarcopenia in the Cirrhotic Patient: Current Knowledge and Future Directions.

Warner Ii E, Satapathy S J Clin Exp Hepatol. 2023; 13(1):162-177.

PMID: 36647414 PMC: 9840086. DOI: 10.1016/j.jceh.2022.06.005.

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