Cutaneous Drug Reactions in the Elderly

Overview

Journal Drugs Aging

Specialties Geriatrics
Pharmacology

Date 2017 Aug 13

PMID 28801750

Citations 3

Authors

James W S Young

Neil H Shear

Affiliations

Soon will be listed here.

Abstract

Cutaneous adverse drug reactions comprise a significant proportion of all adverse drug reactions. They may mimic other dermatologic or systemic illnesses and may cause significant morbidity or mortality. Seven morphologic groups encompass the most commonly encountered cutaneous drug reaction syndromes: exanthematous (maculopapular), dermatitic/eczematous, urticarial, pustular, blistering, purpuric, and erythrodermic. Drug reactions may have significant downstream consequences for the older individual.

Citing Articles

Purpuric Drug Eruption in a Patient with Atopic Dermatitis Treated with Dupilumab.

Wang M, Zheng Q, Tang S, Shen F, Jiang W Acta Derm Venereol. 2022; 102:adv00744.

PMID: 35670327 PMC: 9593475. DOI: 10.2340/actadv.v102.2245.

Eczematous Drug Eruptions.

Blum A, Burgin S Am J Clin Dermatol. 2021; 22(3):349-366.

PMID: 33587283 DOI: 10.1007/s40257-021-00586-8.

An inventory of medicinal products causing skin rash: Clinical and regulatory lessons.

Ancuceanu R, Dinu M, Furtunescu F, Boda D Exp Ther Med. 2019; 18(6):5061-5071.

PMID: 31798726 PMC: 6880410. DOI: 10.3892/etm.2019.7837.

References

McGill V, Kowal-Vern A, Gamelli R . Outcome for older burn patients. Arch Surg. 2000; 135(3):320-5. DOI: 10.1001/archsurg.135.3.320. View

Lange-Asschenfeldt C, Grohmann R, Lange-Asschenfeldt B, Engel R, Ruther E, Cordes J . Cutaneous adverse reactions to psychotropic drugs: data from a multicenter surveillance program. J Clin Psychiatry. 2009; 70(9):1258-65. DOI: 10.4088/JCP.08m04563. View

Chen J, Wang B, Zeng Y, Xu H . High-dose intravenous immunoglobulins in the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese patients: a retrospective study of 82 cases. Eur J Dermatol. 2010; 20(6):743-7. DOI: 10.1684/ejd.2010.1077. View

Harduar-Morano L, Simon M, Watkins S, Blackmore C . Algorithm for the diagnosis of anaphylaxis and its validation using population-based data on emergency department visits for anaphylaxis in Florida. J Allergy Clin Immunol. 2010; 126(1):98-104.e4. PMC: 4158741. DOI: 10.1016/j.jaci.2010.04.017. View

Gonzalez E, Gonzalez S . Drug photosensitivity, idiopathic photodermatoses, and sunscreens. J Am Acad Dermatol. 1996; 35(6):871-85; quiz 886-7. DOI: 10.1016/s0190-9622(96)90108-5. View

Epstein J . Phototoxicity and photoallergy. Semin Cutan Med Surg. 1999; 18(4):274-84. DOI: 10.1016/s1085-5629(99)80026-1. View

Skandalis K, Spirova M, Gaitanis G, Tsartsarakis A, Bassukas I . Drug-induced bullous pemphigoid in diabetes mellitus patients receiving dipeptidyl peptidase-IV inhibitors plus metformin. J Eur Acad Dermatol Venereol. 2011; 26(2):249-53. DOI: 10.1111/j.1468-3083.2011.04062.x. View

Lin T, Hsu M, Lee J . Clinical resemblance of widespread bullous fixed drug eruption to Stevens-Johnson syndrome or toxic epidermal necrolysis: report of two cases. J Formos Med Assoc. 2002; 101(8):572-6. View

Bastuji-Garin S, Fouchard N, Bertocchi M, Roujeau J, Revuz J, Wolkenstein P . SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol. 2000; 115(2):149-53. DOI: 10.1046/j.1523-1747.2000.00061.x. View

10.

Clegg A, Young J, Iliffe S, Rikkert M, Rockwood K . Frailty in elderly people. Lancet. 2013; 381(9868):752-62. PMC: 4098658. DOI: 10.1016/S0140-6736(12)62167-9. View

11.

McGehee W, KLOTZ T, Epstein D, RAPAPORT S . Coumarin necrosis associated with hereditary protein C deficiency. Ann Intern Med. 1984; 101(1):59-60. DOI: 10.7326/0003-4819-101-1-59. View

12.

Miura Y, Ardenghy M, Ramasastry S, Kovach R, Hochberg J . Coumadin necrosis of the skin: report of four patients. Ann Plast Surg. 1996; 37(3):332-7. DOI: 10.1097/00000637-199609000-00017. View

13.

Jones C, Griffiths R, Humphris G, Skirrow P . Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care. Crit Care Med. 2001; 29(3):573-80. DOI: 10.1097/00003246-200103000-00019. View

14.

Goh C, Ling R . A retrospective epidemiology study of contact eczema among the elderly attending a tertiary dermatology referral centre in Singapore. Singapore Med J. 1999; 39(10):442-6. View

15.

Sassolas B, Haddad C, Mockenhaupt M, Dunant A, Liss Y, Bork K . ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson Syndrome and toxic epidermal necrolysis: comparison with case-control analysis. Clin Pharmacol Ther. 2010; 88(1):60-8. DOI: 10.1038/clpt.2009.252. View

16.

Marchetti M, Noland M, Dillon P, Greer K . Taxane associated subacute cutaneous lupus erythematosus. Dermatol Online J. 2013; 19(8):19259. View

17.

Tuchinda P, Chularojanamontri L, Sukakul T, Thanomkitti K, Nitayavardhana S, Jongjarearnprasert K . Cutaneous adverse drug reactions in the elderly: a retrospective analysis in Thailand. Drugs Aging. 2014; 31(11):815-24. DOI: 10.1007/s40266-014-0209-x. View

18.

Darken M, McBurney E . Subacute cutaneous lupus erythematosus-like drug eruption due to combination diuretic hydrochlorothiazide and triamterene. J Am Acad Dermatol. 1988; 18(1 Pt 1):38-42. DOI: 10.1016/s0190-9622(88)70005-5. View

19.

Ahmed A, Moy R . Death in pemphigus. J Am Acad Dermatol. 1982; 7(2):221-8. DOI: 10.1016/s0190-9622(82)70111-2. View

20.

Bastuji-Garin S, Zahedi M, Guillaume J, Roujeau J . Toxic epidermal necrolysis (Lyell syndrome) in 77 elderly patients. Age Ageing. 1993; 22(6):450-6. DOI: 10.1093/ageing/22.6.450. View