» Articles » PMID: 28797105

Regulation of Hepatic Stellate Cell Proliferation and Activation by Glutamine Metabolism

Overview
Journal PLoS One
Date 2017 Aug 11
PMID 28797105
Citations 29
Authors
Affiliations
Soon will be listed here.
Abstract

Conclusion: Glutamine metabolism plays an important role in regulating the proliferation and activation of HSCs. Strategies that are targeted at glutamine metabolism may represent a novel therapeutic approach to the treatment of liver fibrosis.

Citing Articles

Exploring the Antifibrotic Mechanisms of Ghrelin: Modulating TGF-β Signalling in Organ Fibrosis.

Li M, Zheng C, Wang H, Wang S Expert Rev Mol Med. 2024; 27:e8.

PMID: 39569809 PMC: 11879379. DOI: 10.1017/erm.2024.38.


Hepatocellular-Carcinoma-Derived Organoids: Innovation in Cancer Research.

Airola C, Pallozzi M, Cesari E, Cerrito L, Stella L, Sette C Cells. 2024; 13(20.

PMID: 39451244 PMC: 11505656. DOI: 10.3390/cells13201726.


Atractylenolide III Ameliorates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting the PI3K/AKT Pathway and Regulating Glutamine Metabolism.

Wang Y, Shi K, Tu J, Ke C, Chen N, Wang B Molecules. 2023; 28(14).

PMID: 37513376 PMC: 10383814. DOI: 10.3390/molecules28145504.


Organoids: Construction and Application in Gastric Cancer.

Huo C, Zhang X, Gu Y, Wang D, Zhang S, Liu T Biomolecules. 2023; 13(5).

PMID: 37238742 PMC: 10216466. DOI: 10.3390/biom13050875.


Remodeling the hepatic fibrotic microenvironment with emerging nanotherapeutics: a comprehensive review.

Zhao X, Amevor F, Xue X, Wang C, Cui Z, Dai S J Nanobiotechnology. 2023; 21(1):121.

PMID: 37029392 PMC: 10081370. DOI: 10.1186/s12951-023-01876-5.


References
1.
Coe D, Kishore M, Marelli-Berg F . Metabolic regulation of regulatory T cell development and function. Front Immunol. 2014; 5:590. PMC: 4235430. DOI: 10.3389/fimmu.2014.00590. View

2.
Jia Y, Wang Y, Xie J . The Hedgehog pathway: role in cell differentiation, polarity and proliferation. Arch Toxicol. 2015; 89(2):179-91. PMC: 4630008. DOI: 10.1007/s00204-014-1433-1. View

3.
Gross M, Demo S, Dennison J, Chen L, Chernov-Rogan T, Goyal B . Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol Cancer Ther. 2014; 13(4):890-901. DOI: 10.1158/1535-7163.MCT-13-0870. View

4.
Soga T . Cancer metabolism: key players in metabolic reprogramming. Cancer Sci. 2013; 104(3):275-81. PMC: 7657261. DOI: 10.1111/cas.12085. View

5.
Labow B, Souba W . Glutamine. World J Surg. 2001; 24(12):1503-13. DOI: 10.1007/s002680010269. View