Melatonin and Mitochondrial Function During Ischemia/reperfusion Injury

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2017 Aug 11

PMID 28795196

Citations 49

Authors

Zhiqiang Ma

Zhenlong Xin

Wencheng Di

Xiaolong Yan

Xiaofei Li

Russel J Reiter

Yang Yang

Affiliations

Soon will be listed here.

Abstract

Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine, provides a strong defense against IR injury. Mitochondrion, an organelle for ATP production and a decider for cell fate, has been validated to be a crucial target for melatonin to exert its protection against IR injury. In this review, we first clarify the mechanisms underlying mitochondrial dysfunction during IR and melatonin's protection of mitochondria under this condition. Thereafter, special focus is placed on the protective actions of melatonin against IR injury in brain, heart, liver, and others. Finally, we explore several potential future directions of research in this area. Collectively, the information compiled here will serve as a comprehensive reference for the actions of melatonin in IR injury identified to date and will hopefully aid in the design of future research and increase the potential of melatonin as a therapeutic agent.

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References

Gao L, Zhao Y, Liang Y, Lin X, Tan Y, Wu D . The impaired myocardial ischemic tolerance in adult offspring of diabetic pregnancy is restored by maternal melatonin treatment. J Pineal Res. 2016; 61(3):340-52. DOI: 10.1111/jpi.12351. View

Okur M, Arslan S, Aydogdu B, Zeytun H, Basuguy E, Arslan M . Protective Effect of Cordycepin on Experimental Testicular Ischemia/Reperfusion Injury in Rats. J Invest Surg. 2017; 31(1):1-8. DOI: 10.1080/08941939.2016.1246629. View

Yu J, Wei J, Ji L, Hong X . Exploration on mechanism of a new type of melatonin receptor agonist Neu-p11 in hypoxia-reoxygenation injury of myocardial cells. Cell Biochem Biophys. 2014; 70(2):999-1003. DOI: 10.1007/s12013-014-0009-2. View

Manchester L, Coto-Montes A, Boga J, Andersen L, Zhou Z, Galano A . Melatonin: an ancient molecule that makes oxygen metabolically tolerable. J Pineal Res. 2015; 59(4):403-19. DOI: 10.1111/jpi.12267. View

Yip H, Chang Y, Wallace C, Chang L, Tsai T, Chen Y . Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury. J Pineal Res. 2012; 54(2):207-21. DOI: 10.1111/jpi.12020. View

Chouchani E, Pell V, James A, Work L, Saeb-Parsy K, Frezza C . A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury. Cell Metab. 2016; 23(2):254-63. DOI: 10.1016/j.cmet.2015.12.009. View

Yip H, Yang C, Chen K, Huang T, Chen Y, Zhen Y . Combined melatonin and exendin-4 therapy preserves renal ultrastructural integrity after ischemia-reperfusion injury in the male rat. J Pineal Res. 2015; 59(4):434-47. DOI: 10.1111/jpi.12273. View

Dokmeci D, Kanter M, Inan M, Aydogdu N, Basaran U, Yalcin O . Protective effects of ibuprofen on testicular torsion/detorsion-induced ischemia/reperfusion injury in rats. Arch Toxicol. 2007; 81(9):655-63. DOI: 10.1007/s00204-007-0189-2. View

Mukherjee D, Ghosh A, Bandyopadhyay A, Basu A, Datta S, Pattari S . Melatonin protects against isoproterenol-induced alterations in cardiac mitochondrial energy-metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats. J Pineal Res. 2012; 53(2):166-79. DOI: 10.1111/j.1600-079x.2012.00984.x. View

10.

Maessen M, van Mil A, Straathof Y, Riksen N, Rongen G, Hopman M . Impact of lifelong exercise training on endothelial ischemia-reperfusion and ischemic preconditioning in humans. Am J Physiol Regul Integr Comp Physiol. 2017; 312(5):R828-R834. DOI: 10.1152/ajpregu.00466.2016. View

11.

Kaur C, Sivakumar V, Robinson R, Foulds W, Luu C, Ling E . Neuroprotective effect of melatonin against hypoxia-induced retinal ganglion cell death in neonatal rats. J Pineal Res. 2012; 54(2):190-206. DOI: 10.1111/jpi.12016. View

12.

Li Y, Yang Y, Feng Y, Yan J, Fan C, Jiang S . A review of melatonin in hepatic ischemia/reperfusion injury and clinical liver disease. Ann Med. 2014; 46(7):503-11. DOI: 10.3109/07853890.2014.934275. View

13.

Yang Y, Duan W, Jin Z, Yi W, Yan J, Zhang S . JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. J Pineal Res. 2013; 55(3):275-86. DOI: 10.1111/jpi.12070. View

14.

Hu W, Ma Z, Di S, Jiang S, Li Y, Fan C . Snapshot: implications for melatonin in endoplasmic reticulum homeostasis. Br J Pharmacol. 2016; 173(24):3431-3442. PMC: 5120159. DOI: 10.1111/bph.13651. View

15.

Deng Y, Jiao C, Mi C, Xu B, Li Y, Wang F . Melatonin inhibits manganese-induced motor dysfunction and neuronal loss in mice: involvement of oxidative stress and dopaminergic neurodegeneration. Mol Neurobiol. 2014; 51(1):68-88. DOI: 10.1007/s12035-014-8789-3. View

16.

Ramos E, Patino P, Reiter R, Gil-Martin E, Marco-Contelles J, Parada E . Ischemic brain injury: New insights on the protective role of melatonin. Free Radic Biol Med. 2017; 104:32-53. DOI: 10.1016/j.freeradbiomed.2017.01.005. View

17.

Demirtas C, Pasaoglu O, Bircan F, Kantar S, Turkozkan N . The investigation of melatonin effect on liver antioxidant and oxidant levels in fructose-mediated metabolic syndrome model. Eur Rev Med Pharmacol Sci. 2015; 19(10):1915-21. View

18.

Wang W, Fang X, Stephenson L, Zhang X, Khiabani K, Zamboni W . Melatonin attenuates I/R-induced mitochondrial dysfunction in skeletal muscle. J Surg Res. 2010; 171(1):108-13. DOI: 10.1016/j.jss.2010.01.019. View

19.

Zhang Y, Gao X, Garavito R . Biochemical characterization of human dynamin-like protein 1. J Biochem. 2011; 150(6):627-33. DOI: 10.1093/jb/mvr102. View

20.

Oakes S, Papa F . The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol. 2014; 10:173-94. PMC: 5568783. DOI: 10.1146/annurev-pathol-012513-104649. View