Further Linkage Data on Cystic Fibrosis: the Utah Study

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1986 Dec 1

PMID 2879438

Citations 20

Authors

R White

M Leppert

P OConnell

Y Nakamura

S Woodward

M Hoff

J Herbst

M Dean

G Vande Woude

G M Lathrop

Affiliations

Soon will be listed here.

Abstract

We reported earlier complete linkage between cystic fibrosis and an RFLP of the met proto-oncogene revealed by the probe pmetH. Another clone, pmetD, detects another polymorphism with the TaqI restriction enzyme. Further linkage studies, now involving 22 families, have confirmed the tight linkage of cystic fibrosis to the MET and D7S8 loci. Significant allelic association was found between CF and allelic series defined by the pmetH probe.

Citing Articles

Physical and genetic analysis of cosmids from the vicinity of the cystic fibrosis locus.

Scambler P, Estivill X, Bell G, Farrall M, Mclean C, Newman R Nucleic Acids Res. 1987; 15(9):3639-52.

PMID: 3473444 PMC: 340773. DOI: 10.1093/nar/15.9.3639.

Genetic markers on chromosome 7.

Tsui L J Med Genet. 1988; 25(5):294-306.

PMID: 3290488 PMC: 1050454. DOI: 10.1136/jmg.25.5.294.

Two rearranged MET alleles in MNNG-HOS cells reveal the orientation of MET on chromosome 7 to other markers tightly linked to the cystic fibrosis locus.

Park M, Testa J, Blair D, Parsa N, Woude G Proc Natl Acad Sci U S A. 1988; 85(8):2667-71.

PMID: 3282234 PMC: 280059. DOI: 10.1073/pnas.85.8.2667.

Cystic fibrosis.

Harwood I, Rosas F, Edwards D, Kelso J, Nyhan W West J Med. 1988; 148(1):62-9.

PMID: 3277338 PMC: 1026012.

Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.

Beaudet A, Bowcock A, Buchwald M, CAVALLI-SFORZA L, Farrall M, King M Am J Hum Genet. 1986; 39(6):681-93.

PMID: 3026171 PMC: 1684135.

References

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