The Successful Prevention of Thromboembolism Using Rivaroxaban in a Patient with Antithrombin Deficiency During the Perioperative Period

Overview

Journal Intern Med

Specialty General Medicine

Date 2017 Aug 11

PMID 28794370

Citations 4

Authors

Hidetsugu Kawai

Hiromichi Matsushita

Hiroshi Kawada

Yoshiaki Ogawa

Kiyoshi Ando

Affiliations

Soon will be listed here.

Abstract

Antithrombin (AT) deficiency, a rare disorder of the coagulation system, is a serious risk factor for thromboembolism. Approximately 50-90% of patients with AT deficiency develop thromboembolism during their lifetime. In addition, surgery is a major risk factor for thromboembolism in these patients. We herein report the case of a 90-year-old woman with AT deficiency who was safely and successfully managed using rivaroxaban (a direct oral factor Xa inhibitor) during the perioperative period of surgery for right femur fracture. The present case illustrates the effectiveness of rivaroxaban in preventing thromboembolisms due to surgery, even in very elderly patients with antithrombin deficiency. Further investigations are needed to determine the optimal dosage of rivaroxaban.

Citing Articles

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