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Human Fetal Substantia Nigra Grafted to the Dopamine-denervated Striatum of Immunosuppressed Rats: Evidence for Functional Reinnervation

Overview
Journal Neurosci Lett
Specialty Neurology
Date 1986 Nov 21
PMID 2879264
Citations 31
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Abstract

Human fetal substantia nigra tissue, obtained following therapeutic termination of first trimester pregnancies, was grafted to cavities overlying the striatum in ciclosporin-treated rats whose nigrostriatal dopamine system had been removed unilaterally by 6-hydroxydopamine. Tyrosine hydroxylase (TH) immunocytochemistry revealed large numbers of surviving human substantia nigra neurons that matured and formed TH-positive nerve fibers reinnervating the host rat striatum. Apomorphine-induced rotational behavior in grafted animals was reduced by 70-80% in optimal cases 3-5 months after grafting. Thus human fetal dopamine neurons can correct functional deficits in dopamine-denervated rat hosts.

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