RECENT ADVANCES IN TUBERCULOSIS DIAGNOSTIC TECHNIQUES

Overview

Journal Med J Armed Forces India

Specialty General Medicine

Date 2017 Aug 10

PMID 28790679

Authors

P K Menon

K Kapila

V C Ohri

Affiliations

Soon will be listed here.

Abstract

Tuberculosis is re-emerging as an important cause of morbidity and mortality in man. This article outlines current strategies available for the diagnosis of tuberculosis, and its applicability. Fluorescent staming, modified culture methods, antigen detection, ELISA based assays against various antigen preparation and recent advances in molecular techniques have been outlined. Present strategies being developed at Armed Forces Medical College for the early diagnosis, speciation, antibiotic sensitivity testing and epidemiologic testing have also been alluded to.

References

MIDDLEBROOK G, REGGIARDO Z, TIGERTT W . Automatable radiometric detection of growth of Mycobacterium tuberculosis in selective media. Am Rev Respir Dis. 1977; 115(6):1066-9. DOI: 10.1164/arrd.1977.115.6.1066. View

Cousins D, Francis B, Dawson D . Multiplex PCR provides a low-cost alternative to DNA probe methods for rapid identification of Mycobacterium avium and Mycobacterium intracellulare. J Clin Microbiol. 1996; 34(9):2331-3. PMC: 229248. DOI: 10.1128/jcm.34.9.2331-2333.1996. View

Cole S, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D . Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998; 393(6685):537-44. DOI: 10.1038/31159. View

French G, Teoh R, Chan C, Humphries M, Cheung S, OMahony G . Diagnosis of tuberculous meningitis by detection of tuberculostearic acid in cerebrospinal fluid. Lancet. 1987; 2(8551):117-9. DOI: 10.1016/s0140-6736(87)92328-2. View

Zhang Y, Heym B, Allen B, Young D, Cole S . The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature. 1992; 358(6387):591-3. DOI: 10.1038/358591a0. View

Otal I, Martin C, Thierry D, Gicquel B . Restriction fragment length polymorphism analysis using IS6110 as an epidemiological marker in tuberculosis. J Clin Microbiol. 1991; 29(6):1252-4. PMC: 269979. DOI: 10.1128/jcm.29.6.1252-1254.1991. View

Landegren U, Kaiser R, Sanders J, Hood L . A ligase-mediated gene detection technique. Science. 1988; 241(4869):1077-80. DOI: 10.1126/science.3413476. View

Kiehn T, Edwards F . Rapid identification using a specific DNA probe of Mycobacterium avium complex from patients with acquired immunodeficiency syndrome. J Clin Microbiol. 1987; 25(8):1551-2. PMC: 269268. DOI: 10.1128/jcm.25.8.1551-1552.1987. View

Liebana E, Aranaz A, Francis B, Cousins D . Assessment of genetic markers for species differentiation within the Mycobacterium tuberculosis complex. J Clin Microbiol. 1996; 34(4):933-8. PMC: 228920. DOI: 10.1128/jcm.34.4.933-938.1996. View

10.

Cormican M, Glennon M, Riain U, Flynn J . Multiplex PCR for identifying mycobacterial isolates. J Clin Pathol. 1995; 48(3):203-5. PMC: 502438. DOI: 10.1136/jcp.48.3.203. View

11.

Bothamley G, Rudd R, Festenstein F, Ivanyi J . Clinical value of the measurement of Mycobacterium tuberculosis specific antibody in pulmonary tuberculosis. Thorax. 1992; 47(4):270-5. PMC: 463688. DOI: 10.1136/thx.47.4.270. View

12.

Sudre P, Ten Dam G, Kochi A . Tuberculosis: a global overview of the situation today. Bull World Health Organ. 1992; 70(2):149-59. PMC: 2393290. View

13.

Wadee A, Boting L, Reddy S . Antigen capture assay for detection of a 43-kilodalton Mycobacterium tuberculosis antigen. J Clin Microbiol. 1990; 28(12):2786-91. PMC: 268274. DOI: 10.1128/jcm.28.12.2786-2791.1990. View

14.

Jacobs Jr W, Barletta R, Udani R, Chan J, Kalkut G, Sosne G . Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages. Science. 1993; 260(5109):819-22. DOI: 10.1126/science.8484123. View

15.

Herrera E, Perez O, Segovia M . Differentiation between Mycobacterium tuberculosis and Mycobacterium bovis by a multiplex-polymerase chain reaction. J Appl Bacteriol. 1996; 80(6):596-604. DOI: 10.1111/j.1365-2672.1996.tb03263.x. View

16.

HANCE A, Grandchamp B, Lecossier D, Rauzier J, Bocart D, Gicquel B . Detection and identification of mycobacteria by amplification of mycobacterial DNA. Mol Microbiol. 1989; 3(7):843-9. DOI: 10.1111/j.1365-2958.1989.tb00233.x. View

17.

Boddinghaus B, Rogall T, Flohr T, Blocker H, Bottger E . Detection and identification of mycobacteria by amplification of rRNA. J Clin Microbiol. 1990; 28(8):1751-9. PMC: 268042. DOI: 10.1128/jcm.28.8.1751-1759.1990. View

18.

Thierry D, Nguyen S, Guesdon J, Gicquel B . Characterization of a Mycobacterium tuberculosis insertion sequence, IS6110, and its application in diagnosis. J Clin Microbiol. 1990; 28(12):2668-73. PMC: 268253. DOI: 10.1128/jcm.28.12.2668-2673.1990. View

19.

Musser J . Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin Microbiol Rev. 1995; 8(4):496-514. PMC: 172873. DOI: 10.1128/CMR.8.4.496. View

20.

Wilkins E, Ivanyi J . Potential value of serology for diagnosis of extrapulmonary tuberculosis. Lancet. 1990; 336(8716):641-4. DOI: 10.1016/0140-6736(90)92144-7. View