Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2017 Aug 10

PMID 28788032

Citations 48

Authors

Zeeshan Sheikh

Mohammad Ahmad Javaid

Nader Hamdan

Raheel Hashmi

Affiliations

Soon will be listed here.

Abstract

Trauma and disease frequently result in fractures or critical sized bone defects and their management at times necessitates bone grafting. The process of bone healing or regeneration involves intricate network of molecules including bone morphogenetic proteins (BMPs). BMPs belong to a larger superfamily of proteins and are very promising and intensively studied for in the enhancement of bone healing. More than 20 types of BMPs have been identified but only a subset of BMPs can induce bone formation. Many research groups have shown that BMPs can induce differentiation of mesenchymal stem cells and stem cells into osteogenic cells which are capable of producing bone. This review introduces BMPs and discusses current advances in preclinical and clinical application of utilizing various biomaterial carriers for local delivery of BMPs to enhance bone regeneration.

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