The Action of a Dopamine (DA1) Receptor Agonist, Fenoldopam in Human Vasculature in Vivo and in Vitro

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1986 Nov 1

PMID 2878679

Citations 12

Authors

A Hughes

S Thom

G Martin

D Redman

S Hasan

P Sever

Affiliations

Soon will be listed here.

Abstract

This study was designed to investigate dopaminergic mechanisms in human vasculature using the selective vascular dopamine receptor agonist fenoldopam in vivo and in vitro. In vivo, forearm blood flow was measured plethysmographically and in vitro isolated rings of human blood vessels from a variety of sites were used for tissue bath studies. Intra-arterial fenoldopam markedly increased forearm blood flow, this effect was antagonised by (R) sulpiride, a vascular dopamine (DA1) antagonist, but not by metoclopramide, a neuronal (DA2) antagonist, or by guanethidine, an adrenergic neurone blocking agent. In vitro, fenoldopam relaxed preconstricted human renal, mesenteric and lumbar arteries, but not saphenous vein in a concentration dependent manner. (RS) sulpiride and SCH 23390 competitively antagonised this effect. These studies demonstrate the presence of a vasodilatory vascular dopamine receptor in man both in vivo and in vitro.

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