Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2017 Aug 9

PMID 28785583

Citations 9

Authors

Vincent Avecilla

Mayur Doke

Quentin Felty

Affiliations

Soon will be listed here.

Abstract

The overwhelming increase in the global incidence of obesity and its associated complications such as insulin resistance, atherosclerosis, pulmonary disease, and degenerative disorders including dementia constitutes a serious public health problem. The Inhibitor of DNA Binding/Differentiation-3 (ID3), a member of the ID family of transcriptional regulators, has been shown to play a role in adipogenesis and therefore ID3 may influence obesity and metabolic health in response to environmental factors. This review will highlight the current understanding of how ID3 may contribute to complex chronic diseases via metabolic perturbations. Based on the increasing number of reports that suggest chronic exposure to and accumulation of endocrine disrupting chemicals (EDCs) within the human body are associated with metabolic disorders, we will also consider the impact of these chemicals on ID3. Improved understanding of the ID3 pathways by which exposure to EDCs can potentiate complex chronic diseases in populations with metabolic disorders (obesity, metabolic syndrome, and glucose intolerance) will likely provide useful knowledge in the prevention and control of complex chronic diseases associated with exposure to environmental pollutants.

Citing Articles

Pathophysiological Features of Remodeling in Vascular Diseases: Impact of Inhibitor of DNA-Binding/Differentiation-3 and Estrogenic Endocrine Disruptors.

Avecilla V, Doke M, Appunni S, Rubens M, Ramamoorthy V, Das J Med Sci (Basel). 2025; 13(1.

PMID: 39846697 PMC: 11755649. DOI: 10.3390/medsci13010002.

Integrative Bioinformatics-Gene Network Approach Reveals Linkage between Estrogenic Endocrine Disruptors and Vascular Remodeling in Peripheral Arterial Disease.

Avecilla V, Doke M, Das M, Alcazar O, Appunni S, Rech Tondin A Int J Mol Sci. 2024; 25(8).

PMID: 38674087 PMC: 11049860. DOI: 10.3390/ijms25084502.

Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke.

Lu D, Cai H, Li Y, Chang W, Liu X, Dai Q Aging (Albany NY). 2023; 15(24):14803-14829.

PMID: 38112574 PMC: 10781493. DOI: 10.18632/aging.205308.

Transcriptomic Analysis of LNCaP Tumor Xenograft to Elucidate the Components and Mechanisms Contributed by Tumor Environment as Targets for Dietary Prostate Cancer Prevention Studies.

Yu L, Li R, Huang H, Pham Q, Yu L, Wang T Nutrients. 2021; 13(3).

PMID: 33808801 PMC: 8003580. DOI: 10.3390/nu13031000.

The endocrine disruptor cadmium: a new player in the pathophysiology of metabolic diseases.

Bimonte V, Besharat Z, Antonioni A, Cella V, Lenzi A, Ferretti E J Endocrinol Invest. 2021; 44(7):1363-1377.

PMID: 33501614 DOI: 10.1007/s40618-021-01502-x.

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