Novel Durable Antimicrobial Ceramic with Embedded Copper Sub-Microparticles for a Steady-State Release of Copper Ions

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2017 Aug 5

PMID 28773135

Citations 1

Authors

Adam J Drelich

Jessie Miller

Robert Donofrio

Jaroslaw W Drelich

Affiliations

Soon will be listed here.

Abstract

Using pottery clay, porous ceramic stones were molded and then decorated with copper sub-microparticles inside the pores. Copper added antimicrobial functionality to the clay-based ceramic and showed ability in disinfecting water. Populations of both and in contaminated water were reduced by >99.9% in 3 h when exposed to an antimicrobial stone. This antimicrobial performance is attributed to a slow release of copper into water at both room and elevated temperatures. Copper is leached by water to produce ion concentrations in water at a level of 0.05-0.20 ppm after 24 to 72 h immersion tests. This concentration is reproducible over a number of cycles >400. To our knowledge, this is the first formulation of copper sub-microparticles inside the porous structure of commercial-sized ceramic stones that can disinfect bacteria-contaminated water over a period of at least several months.

Citing Articles

Zinc-based alloys for degradable vascular stent applications.

Mostaed E, Sikora-Jasinska M, Drelich J, Vedani M Acta Biomater. 2018; 71:1-23.

PMID: 29530821 PMC: 5927626. DOI: 10.1016/j.actbio.2018.03.005.

References

Borkow G, Gabbay J, Zatcoff R . Could chronic wounds not heal due to too low local copper levels?. Med Hypotheses. 2007; 70(3):610-3. DOI: 10.1016/j.mehy.2007.06.006. View

Valko M, Morris H, Cronin M . Metals, toxicity and oxidative stress. Curr Med Chem. 2005; 12(10):1161-208. DOI: 10.2174/0929867053764635. View

CROSS J, Currier R, Torraco D, Vanderberg L, Wagner G, Gladen P . Killing of bacillus spores by aqueous dissolved oxygen, ascorbic acid, and copper ions. Appl Environ Microbiol. 2003; 69(4):2245-52. PMC: 154791. DOI: 10.1128/AEM.69.4.2245-2252.2003. View

Karlstrom A, Levine R . Copper inhibits the protease from human immunodeficiency virus 1 by both cysteine-dependent and cysteine-independent mechanisms. Proc Natl Acad Sci U S A. 1991; 88(13):5552-6. PMC: 51915. DOI: 10.1073/pnas.88.13.5552. View

Aarestrup F, Hasman H . Susceptibility of different bacterial species isolated from food animals to copper sulphate, zinc chloride and antimicrobial substances used for disinfection. Vet Microbiol. 2004; 100(1-2):83-9. DOI: 10.1016/j.vetmic.2004.01.013. View

Wilks S, Michels H, Keevil C . Survival of Listeria monocytogenes Scott A on metal surfaces: implications for cross-contamination. Int J Food Microbiol. 2006; 111(2):93-8. DOI: 10.1016/j.ijfoodmicro.2006.04.037. View

Stout J, Yu V . Experiences of the first 16 hospitals using copper-silver ionization for Legionella control: implications for the evaluation of other disinfection modalities. Infect Control Hosp Epidemiol. 2003; 24(8):563-8. DOI: 10.1086/502251. View

Malamis S, Katsou E, Stylianou M, Haralambous K, Loizidou M . Copper removal from sludge permeate with ultrafiltration membranes using zeolite, bentonite and vermiculite as adsorbents. Water Sci Technol. 2010; 61(3):581-9. DOI: 10.2166/wst.2010.859. View

Elguindi J, Moffitt S, Hasman H, Andrade C, Raghavan S, Rensing C . Metallic copper corrosion rates, moisture content, and growth medium influence survival of copper ion-resistant bacteria. Appl Microbiol Biotechnol. 2010; 89(6):1963-70. PMC: 3991429. DOI: 10.1007/s00253-010-2980-x. View

10.

Chen Y, Lin Y, Liu Y, Huang W, Shih H, Wann S . Efficacy of point-of-entry copper--silver ionisation system in eradicating Legionella pneumophila in a tropical tertiary care hospital: implications for hospitals contaminated with Legionella in both hot and cold water. J Hosp Infect. 2008; 68(2):152-8. DOI: 10.1016/j.jhin.2007.10.020. View

11.

Liu Y, Kelly D, Yang H, Lin C, Kuznicki S, Xu Z . Novel regenerable sorbent for mercury capture from flue gases of coal-fired power plant. Environ Sci Technol. 2008; 42(16):6205-10. DOI: 10.1021/es800532b. View

12.

Wheeldon L, Worthington T, Lambert P, Hilton A, Lowden C, Elliott T . Antimicrobial efficacy of copper surfaces against spores and vegetative cells of Clostridium difficile: the germination theory. J Antimicrob Chemother. 2008; 62(3):522-5. DOI: 10.1093/jac/dkn219. View

13.

Davies M, Gilbert B, Haywood R . Radical-induced damage to proteins: e.s.r. spin-trapping studies. Free Radic Res Commun. 1991; 15(2):111-27. DOI: 10.3109/10715769109049131. View

14.

Huang H, Shih H, Lee C, Yang T, Lay J, Lin Y . In vitro efficacy of copper and silver ions in eradicating Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Acinetobacter baumannii: implications for on-site disinfection for hospital infection control. Water Res. 2007; 42(1-2):73-80. DOI: 10.1016/j.watres.2007.07.003. View

15.

Avery S, Howlett N, Radice S . Copper toxicity towards Saccharomyces cerevisiae: dependence on plasma membrane fatty acid composition. Appl Environ Microbiol. 1996; 62(11):3960-6. PMC: 168214. DOI: 10.1128/aem.62.11.3960-3966.1996. View

16.

Pereira C, Felcman J . Correlation between five minerals and the healing effect of Brazilian medicinal plants. Biol Trace Elem Res. 1999; 65(3):251-9. DOI: 10.1007/BF02789100. View

17.

Olivares M, Uauy R . Copper as an essential nutrient. Am J Clin Nutr. 1996; 63(5):791S-6S. DOI: 10.1093/ajcn/63.5.791. View

18.

Weaver L, Michels H, Keevil C . Potential for preventing spread of fungi in air-conditioning systems constructed using copper instead of aluminium. Lett Appl Microbiol. 2009; 50(1):18-23. DOI: 10.1111/j.1472-765X.2009.02753.x. View

19.

Soto M, Chavez G, Baez M, Martinez C, Chaidez C . Internalization of Salmonella typhimurium into mango pulp and prevention of fruit pulp contamination by chlorine and copper ions. Int J Environ Health Res. 2007; 17(6):453-9. DOI: 10.1080/09603120701695593. View

20.

Geierstanger B, Kagawa T, Chen S, QUIGLEY G, Ho P . Base-specific binding of copper(II) to Z-DNA. The 1.3-A single crystal structure of d(m5CGUAm5CG) in the presence of CuCl2. J Biol Chem. 1991; 266(30):20185-91. DOI: 10.2210/pdb1d40/pdb. View