Prevention of Gastric Cancer: Eradication of Helicobacter Pylori and Beyond

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2017 Aug 4

PMID 28771198

Citations 36

Authors

Tetsuya Tsukamoto

Mitsuru Nakagawa

Yuka Kiriyama

Takeshi Toyoda

Xueyuan Cao

Affiliations

Soon will be listed here.

Abstract

Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents.

Citing Articles

Identifying the key role of mitochondrial respiration and lipid metabolism in regulating axillary osmidrosis through proteomics analysis.

Gao Q, Liu Y, Huang J, Wang L Arch Dermatol Res. 2024; 317(1):128.

PMID: 39673600 DOI: 10.1007/s00403-024-03616-7.

Experience of negative pressure fractional microneedle radiofrequency therapy for axillary osmidrosis: a case study.

Zhang Y, Li Y, Li C, Tian J Arch Dermatol Res. 2024; 317(1):66.

PMID: 39636411 DOI: 10.1007/s00403-024-03560-6.

lncRNA LINC02323 predicts adverse neoadjuvant chemotherapy outcomes of gastric cancer patients and regulates cell sensitivity to 5-fluorouracil by negatively modulating miR-139-3p.

Chen Z, Zhang X, Li Z, Zhang H, Wang Z Ann Med. 2024; 56(1):2424513.

PMID: 39506605 PMC: 11544739. DOI: 10.1080/07853890.2024.2424513.

Optimized sequential therapy 10- and 14-d concomitant therapy for eradicating : A randomized clinical trial.

Seddik H, Benass J, Berrag S, Sair A, Berraida R, Boutallaka H World J Gastroenterol. 2024; 30(6):556-564.

PMID: 38463026 PMC: 10921140. DOI: 10.3748/wjg.v30.i6.556.

Helicobacter pylori upregulates circPGD and promotes development of gastric cancer.

Zhao W, Yao Z, Cao J, Liu Y, Zhu L, Mao B J Cancer Res Clin Oncol. 2024; 150(2):104.

PMID: 38407616 PMC: 10896836. DOI: 10.1007/s00432-023-05537-w.

References

Bae M, Jang S, Lim J, Kang J, Bak E, Cha J . Protective effect of Korean Red Ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils. J Ginseng Res. 2014; 38(1):8-15. PMC: 3915327. DOI: 10.1016/j.jgr.2013.11.005. View

Lee Y, Chen T, Chiu H, Shun C, Chiang H, Liu T . The benefit of mass eradication of Helicobacter pylori infection: a community-based study of gastric cancer prevention. Gut. 2012; 62(5):676-82. PMC: 3618687. DOI: 10.1136/gutjnl-2012-302240. View

Saka A, Yagi K, Nimura S . Endoscopic and histological features of gastric cancers after successful Helicobacter pylori eradication therapy. Gastric Cancer. 2015; 19(2):524-530. DOI: 10.1007/s10120-015-0479-y. View

Ito M, Tanaka S, Takata S, Oka S, Imagawa S, Ueda H . Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up. Aliment Pharmacol Ther. 2005; 21(5):559-66. DOI: 10.1111/j.1365-2036.2005.02360.x. View

Marone P, Bono L, Leone E, Bona S, Carretto E, Perversi L . Bactericidal activity of Pistacia lentiscus mastic gum against Helicobacter pylori. J Chemother. 2002; 13(6):611-4. DOI: 10.1179/joc.2001.13.6.611. View

Lina T, Alzahrani S, House J, Yamaoka Y, Sharpe A, Rampy B . Helicobacter pylori cag pathogenicity island's role in B7-H1 induction and immune evasion. PLoS One. 2015; 10(3):e0121841. PMC: 4373751. DOI: 10.1371/journal.pone.0121841. View

Kato S, Tsukamoto T, Mizoshita T, Tanaka H, Kumagai T, Ota H . High salt diets dose-dependently promote gastric chemical carcinogenesis in Helicobacter pylori-infected Mongolian gerbils associated with a shift in mucin production from glandular to surface mucous cells. Int J Cancer. 2006; 119(7):1558-66. DOI: 10.1002/ijc.21810. View

Forman D, Newell D, Fullerton F, Yarnell J, Stacey A, Wald N . Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ. 1991; 302(6788):1302-5. PMC: 1670011. DOI: 10.1136/bmj.302.6788.1302. View

JOOSSENS J, Hill M, Elliott P, STAMLER R, Lesaffre E, Dyer A . Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. Int J Epidemiol. 1996; 25(3):494-504. DOI: 10.1093/ije/25.3.494. View

10.

Ohno T, Ohtani M, Suto H, Ohta M, Imamura Y, Matsuda H . Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice. Oncol Rep. 2016; 35(6):3241-7. DOI: 10.3892/or.2016.4717. View

11.

Chiu C, McEntee M, Whelan J . Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis. Cancer Res. 1997; 57(19):4267-73. View

12.

Yanaoka K, Oka M, Ohata H, Yoshimura N, Deguchi H, Mukoubayashi C . Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels. Int J Cancer. 2009; 125(11):2697-703. DOI: 10.1002/ijc.24591. View

13.

Cao X, Tsukamoto T, Seki T, Tanaka H, Morimura S, Cao L . 4-Vinyl-2,6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils. Int J Cancer. 2007; 122(7):1445-54. DOI: 10.1002/ijc.23245. View

14.

Schlemper R, Kato Y, Stolte M . Diagnostic criteria for gastrointestinal carcinomas in Japan and Western countries: proposal for a new classification system of gastrointestinal epithelial neoplasia. J Gastroenterol Hepatol. 2000; 15 Suppl:G49-57. DOI: 10.1046/j.1440-1746.2000.02266.x. View

15.

Shimizu N, Inada K, Nakanishi H, Tsukamoto T, Ikehara Y, Kaminishi M . Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens. Carcinogenesis. 1999; 20(4):669-76. DOI: 10.1093/carcin/20.4.669. View

16.

Cao D, Jiang J, Tsukamoto T, Liu R, Ma L, Jia Z . Canolol inhibits gastric tumors initiation and progression through COX-2/PGE2 pathway in K19-C2mE transgenic mice. PLoS One. 2015; 10(3):e0120938. PMC: 4363315. DOI: 10.1371/journal.pone.0120938. View

17.

Nozaki K, Shimizu N, Tsukamoto T, Inada K, Cao X, Ikehara Y . Reversibility of heterotopic proliferative glands in glandular stomach of Helicobacter pylori-infected Mongolian gerbils on eradication. Jpn J Cancer Res. 2002; 93(4):374-81. PMC: 5927020. DOI: 10.1111/j.1349-7006.2002.tb01267.x. View

18.

El-Omar E, Carrington M, Chow W, McColl K, Bream J, Young H . The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer. Nature. 2002; 412(6842):99. DOI: 10.1038/35083631. View

19.

Toyoda T, Shi L, Takasu S, Cho Y, Kiriyama Y, Nishikawa A . Anti-Inflammatory Effects of Capsaicin and Piperine on Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils. Helicobacter. 2015; 21(2):131-42. DOI: 10.1111/hel.12243. View

20.

Kitamura Y, Ito M, Matsuo T, Boda T, Oka S, Yoshihara M . Characteristic epithelium with low-grade atypia appears on the surface of gastric cancer after successful Helicobacter pylori eradication therapy. Helicobacter. 2014; 19(4):289-95. DOI: 10.1111/hel.12132. View