Immune Response Against Rickettsiae: Lessons from Murine Infection Models

Overview

Journal Med Microbiol Immunol

Specialty Allergy & Immunology

Date 2017 Aug 4

PMID 28770333

Citations 21

Authors

Anke Osterloh

Affiliations

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Abstract

Rickettsiae are small intracellular bacteria that can cause life-threatening febrile diseases. Rickettsioses occur worldwide with increasing incidence. Therefore, a vaccine is highly desired. A prerequisite for the development of a vaccine is the knowledge of the immune response against these bacteria, in particular protective immunity. In recent years murine models of rickettsial infections have been established, and the study of immune response against rickettsiae in mice provided many new insights into protective and pathological immune reactions. This review summarizes the current knowledge about immune mechanisms in protection and pathology in rickettsial infections.

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