Outcome of Surgical Treatment in Late-Onset Capsular Block Syndrome

Overview

Journal J Ophthalmol

Publisher Wiley

Specialty Ophthalmology

Date 2017 Aug 4

PMID 28770106

Citations 4

Authors

Yang Huang

Zi Ye

Hang Li

Zhaohui Li

Affiliations

Soon will be listed here.

Abstract

Purpose: To further investigate the pathogenesis of late-onset capsular block syndrome (CBS) and to evaluate the safety of surgical treatment.

Methods: Seven patients diagnosed with late-onset CBS were retrospectively analyzed. Anterior chamber depth (ACD), intraocular pressure (IOP), refractive diopter, and best-corrected visual acuity (BCVA) before and after surgery were recorded. The opaque substance was tested with Western blot, and a flow cytometer multiple array assay system was utilized to evaluate the levels of inflammatory cytokines from opaque substance and aqueous humor, respectively.

Results: Patients who had undergone surgical treatment showed a significant BCVA and spherical equivalent refractive error improvement ( = 0.002, = 0.021, resp.). Nevertheless, ACD and IOP before and after surgery were in normal range with no difference ( = 0.165, = 0.749, resp.). B-crystallin and B-crystallin were detected in all opaque substances. Tumor necrosis factor-alpha (TNF-) and interlukin-1 (IL-1) levels in opaque substance were significantly higher than those in aqueous humor ( = 0.038, = 0.007, resp.), while IL-2 and IL-6 were not detected in any samples.

Conclusions: Opaque substance is derived from human lens epithelial cells. Inflammatory cytokines may be involved in the pathogenesis of late-onset CBS. In addition, surgical treatment is an effective approach. This trial is registered with ChiCTR-IOR-17011287.

Citing Articles

A potential role for inflammatory cytokines in a rare late-onset capsular block syndrome: a case report.

Du Y, Liang X, Hirooka K, Xia H, Jia Z BMC Ophthalmol. 2024; 24(1):53.

PMID: 38308223 PMC: 10835890. DOI: 10.1186/s12886-024-03320-0.

Anterior Segment Optical Coherence Tomography Findings in Capsular Block Syndrome with Improvement in Myopia following Neodymium-Yttrium Aluminum Garnet Laser Treatment.

Okemoto H, Mito T, Kawamorita T, Sasaki H Case Rep Ophthalmol. 2024; 15(1):78-83.

PMID: 38288025 PMC: 10824525. DOI: 10.1159/000535861.

Femtosecond laser-assisted posterior capsulotomy for the treatment of capsular block syndrome.

Lim X, Patil M, Mehta J Taiwan J Ophthalmol. 2023; 13(3):371-375.

PMID: 38089506 PMC: 10712758. DOI: 10.4103/tjo.TJO-D-23-00042.

Two cases of very late-onset capsular bag distension syndrome.

Galvin J, Berdoukas P, Fung A Am J Ophthalmol Case Rep. 2018; 10:268-270.

PMID: 29780949 PMC: 5956720. DOI: 10.1016/j.ajoc.2018.03.019.

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