Neuroprotective Effects of Ischemic Preconditioning on Hippocampal CA1 Pyramidal Neurons Through Maintaining Calbindin D28k Immunoreactivity Following Subsequent Transient Cerebral Ischemia

Overview

Journal Neural Regen Res

Date 2017 Aug 2

PMID 28761424

Citations 1

Authors

In Hye Kim

Yong Hwan Jeon

Tae-Kyeong Lee

Jeong Hwi Cho

Jae-Chul Lee

Joon Ha Park

Ji Hyeon Ahn

Bich-Na Shin

Yang Hee Kim

Seongkweon Hong

Bing Chun Yan

Moo-Ho Won

Yun Lyul Lee

Affiliations

Soon will be listed here.

Abstract

Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult. In this study, we investigated the neuroprotective effects of ischemic preconditioning (2-minute transient cerebral ischemia) on calbindin D28k immunoreactivity in the gerbil hippocampal CA1 area following a subsequent fatal transient ischemic insult (5-minute transient cerebral ischemia). A large number of pyramidal neurons in the hippocampal CA1 area died 4 days after 5-minute transient cerebral ischemia. Ischemic preconditioning reduced the death of pyramidal neurons in the hippocampal CA1 area. Calbindin D28k immunoreactivity was greatly attenuated at 2 days after 5-minute transient cerebral ischemia and it was hardly detected at 5 days post-ischemia. Ischemic preconditioning maintained calbindin D28k immunoreactivity after transient cerebral ischemia. These findings suggest that ischemic preconditioning can attenuate transient cerebral ischemia-caused damage to the pyramidal neurons in the hippocampal CA1 area through maintaining calbindin D28k immunoreactivity.

Citing Articles

Rosmarinic acid elicits neuroprotection in ischemic stroke Nrf2 and heme oxygenase 1 signaling.

Cui H, Zhang X, Yang Y, Zhang C, Zhu C, Miao J Neural Regen Res. 2018; 13(12):2119-2128.

PMID: 30323140 PMC: 6199925. DOI: 10.4103/1673-5374.241463.

References

Li M, Inoue K, Si H, Xiong Z . Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury. Acta Pharmacol Sin. 2011; 32(6):734-40. PMC: 3395229. DOI: 10.1038/aps.2011.47. View

Lehotsky J, Burda J, Danielisova V, Gottlieb M, Kaplan P, Saniova B . Ischemic tolerance: the mechanisms of neuroprotective strategy. Anat Rec (Hoboken). 2009; 292(12):2002-12. DOI: 10.1002/ar.20970. View

Guo Q, Christakos S, Robinson N, Mattson M . Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function. Proc Natl Acad Sci U S A. 1998; 95(6):3227-32. PMC: 19724. DOI: 10.1073/pnas.95.6.3227. View

Yan B, Ohk T, Ahn J, Park J, Chen B, Lee J . Differences in neuronal damage and gliosis in the hippocampus between young and adult gerbils induced by long duration of transient cerebral ischemia. J Neurol Sci. 2013; 337(1-2):129-36. DOI: 10.1016/j.jns.2013.11.034. View

Heizmann C, Braun K . Changes in Ca(2+)-binding proteins in human neurodegenerative disorders. Trends Neurosci. 1992; 15(7):259-64. DOI: 10.1016/0166-2236(92)90067-i. View

Verdaguer E, Brox S, Petrov D, Olloquequi J, Romero R, de Lemos M . Vulnerability of calbindin, calretinin and parvalbumin in a transgenic/knock-in APPswe/PS1dE9 mouse model of Alzheimer disease together with disruption of hippocampal neurogenesis. Exp Gerontol. 2015; 69:176-88. DOI: 10.1016/j.exger.2015.06.013. View

Kirino T . Delayed neuronal death. Neuropathology. 2000; 20 Suppl:S95-7. DOI: 10.1046/j.1440-1789.2000.00306.x. View

Klapstein G, Vietla S, Lieberman D, Gray P, Airaksinen M, Thoenen H . Calbindin-D28k fails to protect hippocampal neurons against ischemia in spite of its cytoplasmic calcium buffering properties: evidence from calbindin-D28k knockout mice. Neuroscience. 1998; 85(2):361-73. DOI: 10.1016/s0306-4522(97)00632-5. View

Yenari M, Minami M, Sun G, Meier T, Kunis D, McLaughlin J . Calbindin d28k overexpression protects striatal neurons from transient focal cerebral ischemia. Stroke. 2001; 32(4):1028-35. DOI: 10.1161/01.str.32.4.1028. View

10.

Saad M, Abdelsalam R, Kenawy S, Attia A . Ischemic preconditioning and postconditioning alleviates hippocampal tissue damage through abrogation of apoptosis modulated by oxidative stress and inflammation during transient global cerebral ischemia-reperfusion in rats. Chem Biol Interact. 2015; 232:21-9. DOI: 10.1016/j.cbi.2015.03.007. View

11.

Lee J, Tae H, Kim I, Cho J, Lee T, Park J . Roles of HIF-1α, VEGF, and NF-κB in Ischemic Preconditioning-Mediated Neuroprotection of Hippocampal CA1 Pyramidal Neurons Against a Subsequent Transient Cerebral Ischemia. Mol Neurobiol. 2016; 54(9):6984-6998. DOI: 10.1007/s12035-016-0219-2. View

12.

Lee Y, Yan B, Park J, Ahn J, Kim I, Lee J . Differences of calcium binding proteins immunoreactivities in the young hippocampal CA1 region from the adult following transient ischemic damage. J Neurol Sci. 2013; 326(1-2):40-7. DOI: 10.1016/j.jns.2012.12.026. View

13.

Sung J, Shah F, Cho E, Gim S, Jeon S, Kim K . Ginkgo biloba extract (EGb 761) prevents the ischemic brain injury-induced decrease in parvalbumin expression. Lab Anim Res. 2012; 28(2):77-82. PMC: 3389842. DOI: 10.5625/lar.2012.28.2.77. View

14.

Bae E, Chen B, Shin B, Cho J, Kim I, Park J . Comparison of immunoreactivities of calbindin-D28k, calretinin and parvalbumin in the striatum between young, adult and aged mice, rats and gerbils. Neurochem Res. 2015; 40(4):864-72. DOI: 10.1007/s11064-015-1537-x. View

15.

Lee J, Cho J, Kim I, Ahn J, Park J, Cho G . Ischemic preconditioning inhibits expression of Na(+)/H(+) exchanger 1 (NHE1) in the gerbil hippocampal CA1 region after transient forebrain ischemia. J Neurol Sci. 2015; 351(1-2):146-153. DOI: 10.1016/j.jns.2015.03.008. View

16.

Kim I, Yoo K, Park J, Yan B, Ahn J, Lee J . Comparison of neuroprotective effects of extract and fractions from Agarum clathratum against experimentally induced transient cerebral ischemic damage. Pharm Biol. 2013; 52(3):335-43. DOI: 10.3109/13880209.2013.837074. View

17.

Fan Y, Shi L, Gu Y, Zhao Y, Xie J, Qiao J . Pretreatment with PTD-calbindin D 28k alleviates rat brain injury induced by ischemia and reperfusion. J Cereb Blood Flow Metab. 2006; 27(4):719-28. DOI: 10.1038/sj.jcbfm.9600373. View

18.

Koh P . Nicotinamide restores the reduction of parvalbumin in cerebral ischemic injury. J Vet Med Sci. 2012; 75(2):225-9. DOI: 10.1292/jvms.12-0216. View

19.

Thompson J, Dave K, Young J, Perez-Pinzon M . Ischemic preconditioning alters the epigenetic profile of the brain from ischemic intolerance to ischemic tolerance. Neurotherapeutics. 2013; 10(4):789-97. PMC: 3805868. DOI: 10.1007/s13311-013-0202-9. View

20.

DOrlando C, Fellay B, Schwaller B, Salicio V, Bloc A, Gotzos V . Calretinin and calbindin D-28k delay the onset of cell death after excitotoxic stimulation in transfected P19 cells. Brain Res. 2001; 909(1-2):145-58. DOI: 10.1016/s0006-8993(01)02671-3. View