Chicken Hepatic Response to Chronic Heat Stress Using Integrated Transcriptome and Metabolome Analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Aug 1

PMID 28759571

Citations 55

Authors

Sara F Jastrebski

Susan J Lamont

Carl J Schmidt

Affiliations

Soon will be listed here.

Abstract

The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation.

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