Body Composition in Adolescents During Treatment With Selective Serotonin Reuptake Inhibitors

Overview

Journal Pediatrics

Specialty Pediatrics

Date 2017 Aug 1

PMID 28759400

Citations 14

Authors

Chadi A Calarge

James A Mills

Kathleen F Janz

Trudy L Burns

William H Coryell

Babette S Zemel

Affiliations

Soon will be listed here.

Abstract

Objectives: To examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) to changes in body composition in older adolescents.

Methods: Medically healthy 15- to 20-year-olds who were unmedicated or within 1 month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Body Mass Index (BMI) was measured every 4 months. Every 8 months, a whole-body dual-energy radiograph absorptiometry scan was obtained to determine lean BMI, fat mass index, and visceral fat mass. Linear mixed effects regression analysis examined associations between MDD, GAD, and SSRI use variables and body composition measures.

Results: Over 1.51 ± 0.76 years of follow-up, 264 participants contributed 805 observations. After adjusting for age, sex, physical activity, dietary intake, and time in the study, MDD severity was inversely associated, prospectively, with BMI, fat mass index, and lean BMI scores, whereas cumulative SSRI treatment duration and dose were positively associated with these outcomes. GAD severity and diagnosis were not significantly associated with any body composition outcome. Moreover, citalopram and escitalopram were most strongly associated with the increase in all body composition measures, including visceral fat mass, whereas the associations with fluoxetine were somewhat weaker. Sertraline was not different from no SSRI treatment.

Conclusions: Depression severity was associated with a decrease in measures of body composition in older adolescents over a mean of 1.5 years, whereas SSRI treatment was positively associated with these outcomes, with differential effects across treatment groups.

Citing Articles

Fluoxetine and Sertraline Inhibit Height Growth and Growth Hormone Signaling During Puberty.

Calarge C, Amushie C, Dinh S, Mills J, Devaraj S, Barba-Villalobos G J Clin Psychopharmacol. 2024; 44(6):538-544.

PMID: 39392873 PMC: 11753947. DOI: 10.1097/JCP.0000000000001922.

Mechanisms Involved in the Link between Depression, Antidepressant Treatment, and Associated Weight Change.

Kukucka T, Ferencova N, Visnovcova Z, Ondrejka I, Hrtanek I, Kovacova V Int J Mol Sci. 2024; 25(8).

PMID: 38674096 PMC: 11050075. DOI: 10.3390/ijms25084511.

Examining Whether Genetic Variants Moderate the Skeletal Effects of Selective Serotonin Reuptake Inhibitors in Older Adolescents and Young Adults.

Ezenwabachili I, Deumic Shultz E, Mills J, Ellingrod V, Calarge C J Child Adolesc Psychopharmacol. 2023; 33(7):260-268.

PMID: 37579130 PMC: 10517324. DOI: 10.1089/cap.2023.0007.

Pediatric Psychopharmacology for Depressive and Anxiety Disorders.

Strawn J, Vaughn S, Ramsey L Focus (Am Psychiatr Publ). 2023; 20(2):184-190.

PMID: 37153132 PMC: 10153505. DOI: 10.1176/appi.focus.20210036.

Adverse Effects of Antidepressant Medications and their Management in Children and Adolescents.

Strawn J, Mills J, Poweleit E, Ramsey L, Croarkin P Pharmacotherapy. 2023; 43(7):675-690.

PMID: 36651686 PMC: 10378577. DOI: 10.1002/phar.2767.

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