Association of Serum C1q/TNF-related Protein-3 (CTRP-3) in Patients with Coronary Artery Disease

Overview

Journal BMC Cardiovasc Disord

Publisher Biomed Central

Specialty Cardiology & Vascular Diseases

Date 2017 Jul 30

PMID 28754090

Citations 7

Authors

Shuhong Wang

Yuan Ling

Wei Liang

Linhui Shen

Affiliations

Soon will be listed here.

Abstract

Background: Recent studies have demonstrated that complement C1q tumor necrosis factor related proteins (CTRPs) have diverse biological influences on the cardiovascular system. CTRP 3 is a member of the CTRP superfamily, which may play a pivotal role in the pathogenesis of coronary artery disease (CAD). Here, we investigated whether serum levels of CTRP 3 are associated with the prevalence and the severity of CAD.

Methods: In this study, 145 eligible participants were included who underwent coronary angiography. According to the result of the coronary angiography, all participants were divided into two groups: non-CAD group (n = 66) and CAD group (n = 79). The CAD group was further divided into single-vessel (n = 25), double-vessel (n = 30) and triple-vessel (n = 24) disease groups in line with different lesioned vessels of CAD. Plasma CTRP 3 concentration was determined by enzyme-linked immunosorbent assay (ELISA).

Results: Serum levels of CTRP 3 were significantly higher in CAD patients than in non-CAD patients (CAD: 56.68 ± 3.63 ng/ml, non-CAD: 44.10 ± 3.20 ng/ml, p < 0.01). Significant differences of CTRP 3 levels were also found between single-vessel group and triple-vessel group (single-vessel group: 44.80 ± 3.14 ng/ml, triple-vessel group: 75.07 ± 9.41 ng/ml, p < 0.005). Multiple logistic regression analysis revealed that CTRP 3 levels, together with HDL cholesterol and glucose, correlated with CAD.

Conclusions: Elevated serum CTRP 3 levels were closely related to the prevalence and severity of CAD, suggesting that it might be regarded as a novel biomarker for CAD.

Citing Articles

Association of serum 25-hydroxyvitamin D3, fibroblast growth factor-23, and C1q/tumor necrosis factor-related protein-3 with coronary artery calcification in nondialysis chronic kidney disease patients.

Zhu Y, Hu Z, Liu Y, Qin C, Chen X, Shi Y Ren Fail. 2023; 45(1):2220412.

PMID: 37293793 PMC: 10259302. DOI: 10.1080/0886022X.2023.2220412.

CTRP-3 Levels in Patients with Stable Coronary Artery Disease and Paroxysmal Atrial Fibrillation: A New Potential Biomarker in Cardiovascular Diseases.

Mourilhe-Rocha R, Bittencourt M Arq Bras Cardiol. 2022; 118(1):59-60.

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The circulating levels of CTRP1 and CTRP5 are associated with obesity indices and carotid intima-media thickness (cIMT) value in patients with type 2 diabetes: a preliminary study.

Majidi Z, Emamgholipour S, Omidifar A, Rahmani Fard S, Poustchi H, Shanaki M Diabetol Metab Syndr. 2021; 13(1):14.

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Geca T, Kwiatek M, Krzyzanowski A, Kwasniewska A J Clin Med. 2020; 9(8).

PMID: 32785102 PMC: 7465884. DOI: 10.3390/jcm9082587.

CTRP9 Mediates Protective Effects in Cardiomyocytes via AMPK- and Adiponectin Receptor-Mediated Induction of Anti-Oxidant Response.

Niemann B, Li L, Siegler D, Siegler B, Knapp F, Hanna J Cells. 2020; 9(5).

PMID: 32429302 PMC: 7291146. DOI: 10.3390/cells9051229.

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