Concise Review: Stem Cells for Corneal Wound Healing

Overview

Journal Stem Cells

Publisher Oxford University Press

Specialties Cell Biology
Reproductive Medicine

Date 2017 Jul 28

PMID 28748596

Citations 49

Authors

Mehrnoosh Saghizadeh

Andrei A Kramerov

Clive N Svendsen

Alexander V Ljubimov

Affiliations

Soon will be listed here.

Abstract

Corneal wound healing is a complex process that occurs in response to various injuries and commonly used refractive surgery. It is a significant clinical problem, which may lead to serious complications due to either incomplete (epithelial) or excessive (stromal) healing. Epithelial stem cells clearly play a role in this process, whereas the contribution of stromal and endothelial progenitors is less well studied. The available evidence on stem cell participation in corneal wound healing is reviewed, together with the data on the use of corneal and non-corneal stem cells to facilitate this process in diseased or postsurgical conditions. Important aspects of corneal stem cell generation from alternative cell sources, including pluripotent stem cells, for possible transplantation upon corneal injuries or in disease conditions are also presented. Stem Cells 2017;35:2105-2114.

Citing Articles

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys.

Zhou M, Shi Z, Liu Z, Ke S, Wang C, Liang X Invest Ophthalmol Vis Sci. 2024; 65(11):43.

PMID: 39330987 PMC: 11437678. DOI: 10.1167/iovs.65.11.43.

Targeting limbal epithelial stem cells: master conductors of corneal epithelial regeneration from the bench to multilevel theranostics.

Li S, Sun H, Chen L, Fu Y J Transl Med. 2024; 22(1):794.

PMID: 39198892 PMC: 11350997. DOI: 10.1186/s12967-024-05603-y.

Extracellular Vesicles Isolated from Equine Adipose-Derived Stromal Stem Cells (ASCs) Mitigate Tunicamycin-Induced ER Stress in Equine Corneal Stromal Stem Cells (CSSCs).

Meissner J, Chmielinska A, Ofri R, Cislo-Sankowska A, Marycz K Curr Issues Mol Biol. 2024; 46(4):3251-3277.

PMID: 38666934 PMC: 11048834. DOI: 10.3390/cimb46040204.

MicroRNA and Protein Cargos of Human Limbal Epithelial Cell-Derived Exosomes and Their Regulatory Roles in Limbal Stromal Cells of Diabetic and Non-Diabetic Corneas.

Verma N, Khare D, Poe A, Amador C, Ghiam S, Fealy A Cells. 2023; 12(21).

PMID: 37947602 PMC: 10649916. DOI: 10.3390/cells12212524.

Wound healing of the corneal epithelium: a review.

Ghafar N, Abdul Jalil N, Kamarudin T Asian Biomed (Res Rev News). 2023; 15(5):199-212.

PMID: 37551323 PMC: 10388779. DOI: 10.2478/abm-2021-0026.

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