Sex Differences of In-hospital Outcome and Long-term Mortality in Patients with Takotsubo Cardiomyopathy

Overview

Journal Ther Clin Risk Manag

Publisher Dove Medical Press

Date 2017 Jul 27

PMID 28744135

Citations 5

Authors

K J Weidner

I El-Battrawy

M Behnes

K Schramm

C Fastner

J Kuschyk

U Hoffmann

U Ansari

M Borggrefe

I Akin

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies revealed that patients with Takotsubo cardiomyopathy (TTC) have a higher mortality rate than the general population. It is still unclear whether sex differences may influence long-term prognosis of TTC patients. The purpose of this study was to determine whether sex differences do influence the short- and long-term outcomes of TTC.

Methods And Results: A total of 114 patients with TTC were admitted to the University Medical Centre Mannheim from January 2003 to September 2015 and entered into the TTC database of the University Medical Centre Mannheim, and retrospectively analyzed. Patients were diagnosed by the Mayo Clinic criteria. All-cause mortality over mean follow-up of 1,529±1,121 days was revealed. Significantly more male patients died within long-term follow-up compared to female TTC patients (log-rank test; =0.01). Most males died of noncardiac causes. In multivariate Cox regression analysis, the male sex (=0.02, hazard ratio [HR] 2.8, 95% CI 1.1-7.2), the ejection fraction ≤35% (=0.01, HR 3.3, 95% CI 1.2-9.2) and glomerular filtration rate <60 mL/min (<0.01, HR 3.1, 95% CI 1.4-7.0) figured out as independent predictors of the adverse outcome.

Conclusion: This study shows that males suffering from TTC reveal a higher long-term all-cause mortality rate than females over a 5 year follow-up period.

Citing Articles

Contemporary characteristics, outcomes and novel risk score for Takotsubo cardiomyopathy: a national inpatient sample analysis.

Agrawal A, Bhagat U, Yesilyaprak A, Bayat A, Sawhney A, Arockiam A Open Heart. 2024; 11(2).

PMID: 39375178 PMC: 11459304. DOI: 10.1136/openhrt-2024-002922.

Sex Differences in Stress-Induced (Takotsubo) Cardiomyopathy.

Maskoun W, Alqam B, Habash F, Gheith Z, Sawada S, Vallurupalli S CJC Open. 2023; 5(2):120-127.

PMID: 36880077 PMC: 9984900. DOI: 10.1016/j.cjco.2022.11.012.

Prognostic factors of Takotsubo cardiomyopathy: a systematic review.

Lu X, Li P, Teng C, Cai P, Jin L, Li C ESC Heart Fail. 2021; 8(5):3663-3689.

PMID: 34374223 PMC: 8497208. DOI: 10.1002/ehf2.13531.

Comparison of Outcomes in Patients With Takotsubo Syndrome With-vs-Without Cardiogenic Shock.

Syed M, Khan M, Osman M, Alharbi A, Khan M, Munir M Am J Cardiol. 2020; 136:24-31.

PMID: 32941812 PMC: 8375056. DOI: 10.1016/j.amjcard.2020.09.014.

Importance of sympathetic nervous system activity during left ventricular functional recovery and its association with in-hospital complications in Takotsubo syndrome.

Matsuura T, Ueno M, Iwanaga Y, Miyazaki S Heart Vessels. 2019; 34(8):1317-1324.

PMID: 30796565 DOI: 10.1007/s00380-019-01359-4.

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