Integrin β3/Akt Signaling Contributes to Platelet-induced Hemangioendothelioma Growth

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jul 27

PMID 28744026

Citations 4

Authors

Rui Gu

Xin Sun

Yijie Chi

Qishuang Zhou

Hongkai Xiang

Dale B Bosco

Xinhe Lai

Caixia Qin

Kwok-Fai So

Yi Ren

Xiao-Ming Chen

Affiliations

Soon will be listed here.

Abstract

Hemangioendothelioma (HE) is a type of angiomatous lesions that features endothelial cell proliferation. Understanding the mechanisms orchestrating HE angiogenesis can provide therapeutic insights. It has been shown that platelets can support normal and malignant endothelial cells during angiogenesis. Using the mouse endothelial-derived EOMA cell line as a model of HE, we explored the regulatory effect of platelets. We found that platelets stimulated EOMA proliferation but did not mitigate apoptosis. Furthermore, direct platelet-EOMA cell contact was required and the proliferation was mediated via integrin β3/Akt signaling in EOMA cells. SiRNA knockdown of integrin β3 and inhibition of Akt activity significantly abolished platelet-induced EOMA cell proliferation in vitro and tumor development in vivo. These results provide a new mechanism by which platelets support HE progression and suggest integrin β3 as a potential target to treat HE.

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