Relation Between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jul 26

PMID 28740206

Citations 20

Authors

Natalie Arnold

Tommaso Gori

Renate B Schnabel

Andreas Schulz

Jurgen H Prochaska

Tanja Zeller

Harald Binder

Norbert Pfeiffer

Manfred Beutel

Christine Espinola-Klein

Karl J Lackner

Stefan Blankenberg

Thomas Munzel

Philipp S Wild

Affiliations

Soon will be listed here.

Abstract

The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured. Multivariable linear regression analysis with adjustment for cardiovascular risk factors, medication, and hormonal status (in females) revealed an independent association between SI and WBCC, IL-1RA and hematocrit in both sexes, and with fibrinogen in women. There was a joint effect of increasing tertiles of SI and biomarker concentrations for future CVD risk prediction. Subjects with both SI and biomarker concentration above the median had the worst overall survival and with both below the median the best survival during a follow-up period of 6.2 ± 1.7 years, except for hematocrit. The results support the relation between inflammation, hemostasis and arterial stiffness measured by digital photoplethysmography. Markers of inflammation and hemostasis modulate the ability of SI to identify subjects at risk for future CVD or higher mortality.

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References

Krishnan S, Sobey C, Latz E, Mansell A, Drummond G . IL-1β and IL-18: inflammatory markers or mediators of hypertension?. Br J Pharmacol. 2014; 171(24):5589-602. PMC: 4290704. DOI: 10.1111/bph.12876. View

Tomiyama H, Hashimoto H, Tanaka H, Matsumoto C, Odaira M, Yamada J . Continuous smoking and progression of arterial stiffening: a prospective study. J Am Coll Cardiol. 2010; 55(18):1979-87. DOI: 10.1016/j.jacc.2009.12.042. View

DAWBER T, THOMAS Jr H, MCNAMARA P . Characteristics of the dicrotic notch of the arterial pulse wave in coronary heart disease. Angiology. 1973; 24(4):244-55. DOI: 10.1177/000331977302400407. View

Schnabel R, Larson M, Dupuis J, Lunetta K, Lipinska I, Meigs J . Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection. Hypertension. 2008; 51(6):1651-7. PMC: 2892983. DOI: 10.1161/HYPERTENSIONAHA.107.105668. View

Epstein S, Vergnaud A, Elliott P, Chowienczyk P, Alastruey J . Numerical assessment of the stiffness index. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2014:1969-72. DOI: 10.1109/EMBC.2014.6943999. View

TAQUET A, Bonithon-Kopp C, Simon A, Levenson J, Scarabin Y, Malmejac A . Relations of cardiovascular risk factors to aortic pulse wave velocity in asymptomatic middle-aged women. Eur J Epidemiol. 1993; 9(3):298-306. DOI: 10.1007/BF00146267. View

Wu J, Saleh M, Kirabo A, Itani H, Montaniel K, Xiao L . Immune activation caused by vascular oxidation promotes fibrosis and hypertension. J Clin Invest. 2015; 126(1):50-67. PMC: 4701546. DOI: 10.1172/JCI80761. View

Sesso H, Buring J, Rifai N, J Blake G, Gaziano J, Ridker P . C-reactive protein and the risk of developing hypertension. JAMA. 2003; 290(22):2945-51. DOI: 10.1001/jama.290.22.2945. View

DAgostino Sr R, Vasan R, Pencina M, Wolf P, Cobain M, Massaro J . General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation. 2008; 117(6):743-53. DOI: 10.1161/CIRCULATIONAHA.107.699579. View

10.

Herder C, Dalmas E, Boni-Schnetzler M, Donath M . The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications. Trends Endocrinol Metab. 2015; 26(10):551-563. DOI: 10.1016/j.tem.2015.08.001. View

11.

Millasseau S, Ritter J, Takazawa K, Chowienczyk P . Contour analysis of the photoplethysmographic pulse measured at the finger. J Hypertens. 2006; 24(8):1449-56. DOI: 10.1097/01.hjh.0000239277.05068.87. View

12.

Puddu P, Lanti M, Menotti A, Mancini M, Zanchetti A, Cirillo M . Red blood cell count in short-term prediction of cardiovascular disease incidence in the Gubbio population study. Acta Cardiol. 2002; 57(3):177-85. DOI: 10.2143/AC.57.3.2005387. View

13.

Laurent S, Cockcroft J, van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D . Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006; 27(21):2588-605. DOI: 10.1093/eurheartj/ehl254. View

14.

Lowe G . Rheological influences on thrombosis. Baillieres Best Pract Res Clin Haematol. 2000; 12(3):435-49. DOI: 10.1053/beha.1999.0035. View

15.

Puddu P, Menotti A, Tolonen H, Nedeljkovic S, Kafatos A . Determinants of 40-year all-cause mortality in the European cohorts of the Seven Countries Study. Eur J Epidemiol. 2011; 26(8):595-608. DOI: 10.1007/s10654-011-9600-7. View

16.

Voloshyna I, Littlefield M, Reiss A . Atherosclerosis and interferon-γ: new insights and therapeutic targets. Trends Cardiovasc Med. 2013; 24(1):45-51. PMC: 3844070. DOI: 10.1016/j.tcm.2013.06.003. View

17.

Lukens J, Gross J, Kanneganti T . IL-1 family cytokines trigger sterile inflammatory disease. Front Immunol. 2012; 3:315. PMC: 3466588. DOI: 10.3389/fimmu.2012.00315. View

18.

McEniery C, Wilkinson I . Large artery stiffness and inflammation. J Hum Hypertens. 2005; 19(7):507-9. DOI: 10.1038/sj.jhh.1001814. View

19.

Wild P, Zeller T, Beutel M, Blettner M, Dugi K, Lackner K . [The Gutenberg Health Study]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012; 55(6-7):824-9. DOI: 10.1007/s00103-012-1502-7. View

20.

Floege J, Ketteler M . Vascular calcification in patients with end-stage renal disease. Nephrol Dial Transplant. 2004; 19 Suppl 5:V59-66. DOI: 10.1093/ndt/gfh1058. View