Sleep Characteristics and Risk of Dementia and Alzheimer's Disease: The Atherosclerosis Risk in Communities Study

Overview

Journal Alzheimers Dement

Specialties Neurology
Psychiatry

Date 2017 Jul 25

PMID 28738188

Citations 80

Authors

Pamela L Lutsey

Jeffrey R Misialek

Thomas H Mosley

Rebecca F Gottesman

Naresh M Punjabi

Eyal Shahar

Richard MacLehose

Rachel P Ogilvie

David Knopman

Alvaro Alonso

Affiliations

Soon will be listed here.

Abstract

Introduction: This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short and long sleep duration are associated with dementia over 15 years of follow-up.

Methods: A total of 1667 Atherosclerosis Risk in Communities Study participants underwent in-home polysomnography (1996-1998) and were followed for dementia. Dementia was defined by (1) hospitalization diagnosis codes (1996-2012) and (2) a comprehensive neurocognitive examination (2011-2013) with adjudication.

Results: OSA and sleep duration were not associated with risk of incident dementia. When using adjudicated outcomes, severe OSA (≥30 vs. <5 apnea-hypopnea events/hour) was associated with higher risk of all-cause dementia (risk ratio [95% confidence interval], 2.35 [1.06-5.18]) and Alzheimer's disease dementia (1.66 [1.03-2.68]); associations were attenuated with cardiovascular risk factor adjustment. Sleeping <7 versus 8 to ≤9 hours was associated with higher risk of all-cause dementia (2.00 [1.03-3.86]).

Discussion: When adjudicated outcome definitions were used, late-midlife OSA and short sleep duration were associated with all-cause and Alzheimer's disease dementia in later life.

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