Functional Comparison for Lipid Metabolism and Intestinal and Fecal Microflora Enzyme Activities Between Low Molecular Weight Chitosan and Chitosan Oligosaccharide in High-Fat-Diet-Fed Rats

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2017 Jul 25

PMID 28737708

Citations 14

Authors

Chen-Yuan Chiu

Shih-An Feng

Shing-Hwa Liu

Meng-Tsan Chiang

Affiliations

Soon will be listed here.

Abstract

The present study investigated and compared the regulatory effects on the lipid-related metabolism and intestinal disaccharidase/fecal bacterial enzyme activities between low molecular weight chitosan and chitosan oligosaccharide in high-fat-diet-fed rats. Diet supplementation of low molecular weight chitosan showed greater efficiency than chitosan oligosaccharide in suppressing the increased weights in body and in liver and adipose tissues of high-fat-diet-fed rats. Supplementation of low molecular weight chitosan also showed a greater improvement than chitosan oligosaccharide in imbalance of plasma, hepatic, and fecal lipid profiles, and intestinal disaccharidase activities in high-fat-diet-fed rats. Moreover, both low molecular weight chitosan and chitosan oligosaccharide significantly decreased the fecal microflora mucinase and β-glucuronidase activities in high-fat-diet-fed rats. These results suggest that low molecular weight chitosan exerts a greater positive improvement than chitosan oligosaccharide in lipid metabolism and intestinal disaccharidase activity in high-fat-diet-induced obese rats.

Citing Articles

Synergistic Effects of Chitosan and Fish Oil on Lipid Metabolism in Rats Fed a High-Fat and Low-Carbohydrate Diet.

Liu S, Chang T, Liu S, Chiang M Nutrients. 2024; 16(23).

PMID: 39683472 PMC: 11643443. DOI: 10.3390/nu16234080.

Anti-Obesity Effects of Chitosan and Its Derivatives.

Shagdarova B, Konovalova M, Varlamov V, Svirshchevskaya E Polymers (Basel). 2023; 15(19).

PMID: 37836016 PMC: 10575173. DOI: 10.3390/polym15193967.

Antidiabetic Properties of Chitosan and Its Derivatives.

Tzeng H, Liu S, Chiang M Mar Drugs. 2022; 20(12).

PMID: 36547931 PMC: 9782916. DOI: 10.3390/md20120784.

Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities.

Li J, Duan H, Liu Y, Wang L, Zhou X Pharmaceutics. 2022; 14(7).

PMID: 35890340 PMC: 9320151. DOI: 10.3390/pharmaceutics14071445.

Chitosan Oligosaccharide Ameliorates Metabolic Syndrome Induced by Overnutrition Altering Intestinal Microbiota.

Wang Y, Liu S, Tang D, Dong R, Feng Q Front Nutr. 2021; 8:743492.

PMID: 34660667 PMC: 8517441. DOI: 10.3389/fnut.2021.743492.

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