Genetic Variants of Increased Waist Circumference in Psychosis

Overview

Journal Psychiatr Genet

Specialty Neurology

Date 2017 Jul 25

PMID 28737528

Citations 2

Authors

Dzana S Hukic

Urban Osby

Eric Olsson

Agneta Hilding

Claes-Goran Ostenson

Harvest F Gu

Ewa Ehrenborg

Gunnar Edman

Martin Schalling

Catharina Lavebratt

Louise Frisen

Affiliations

Soon will be listed here.

Abstract

Objective: We examined whether established metabolic risk genetic variants in the population confer a risk for increased waist circumference in patients with schizophrenia spectrum disorders and also an association with schizophrenia spectrum disorders irrespective of waist circumference.

Patients And Methods: We analyzed the association in (i) a case-case model in which patients with schizophrenia spectrum disorder with increased waist circumference (≥80 cm for women and ≥94 cm for men) (n=534) were compared with patients with normal waist circumference (<80 cm for women; <94 cm for men) (n=124), and in (ii) a case-control model in which schizophrenia spectrum disorder patients with increased waist circumference or irrespective of waist circumference were compared with population-derived controls (n=494) adjusted for age, sex, fasting glucose, smoking, and family history of diabetes.

Results: Genetic variants in five genes (MIA3, MRAS, P2RX7, CAMKK2, and SMAD3) were associated with increased waist circumference in patients with schizophrenia spectrum disorder (P<0.046). Genetic variants in three other genes (PPARD, MNTR1B, and NOTCH2) were associated with increased waist circumference in patients when compared with control individuals (P<0.037). Genetic variants in the PPARD, MNTR1B, NOTCH2, and HNF1B were nominally associated with schizophrenia spectrum disorder irrespective of waist circumference (P<0.027). No differences in waist circumference between specific psychosis diagnoses were detected.

Conclusion: Increased waist circumference in patients with schizophrenia spectrum disorder may be explained, in part, by increased metabolic risk gene burden, and it indicates a shared genetic susceptibility to metabolic disorder and psychosis per se. Along these lines, common metabolic risk genetic variants confer a risk for increased waist circumference in patients with schizophrenia spectrum disorders.

Citing Articles

PPARD May Play a Protective Role against the Development of Schizophrenia.

Li X, Liu S, Kapoor K, Xu Y PPAR Res. 2020; 2020:3480412.

PMID: 32831816 PMC: 7428834. DOI: 10.1155/2020/3480412.

Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment.

Kumar P, Efstathopoulos P, Millischer V, Olsson E, Wei Y, Brustle O Sci Rep. 2018; 8(1):12743.

PMID: 30143692 PMC: 6109159. DOI: 10.1038/s41598-018-31122-0.

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