Impact of Thyroid Function Abnormalities on Reproductive Hormones During Menstrual Cycle in Premenopausal HIV Infected Females at NAUTH, Nnewi, Nigeria

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Jul 21

PMID 28723963

Citations 6

Authors

Nkiruka Rose Ukibe

Solomon Nwabueze Ukibe

Obiageli Fidelia Emelumadu

Chinedum Charles Onyenekwe

Joseph Eberendu Ahaneku

Anthony Osita Igwegbe

Ifeoma Nwamaka Monago

Amobi Linus Ilika

Affiliations

Soon will be listed here.

Abstract

Background: This was a prospective study designed to evaluate the impact of thyroid function abnormalities on reproductive hormones during menstrual cycle in HIV infected females at Nnamdi Azikiwe University Teaching Hospital Nnewi, South-East Nigeria.

Methods: The study randomly recruited 35 Symptomatic HIV infected females and 35 Symptomatic HIV infected females on antiretroviral therapy (HAART) for not less than six weeks from an HIV clinic and 40 apparently heathy control females among the hospital staff of NAUTH Nnewi. They were all premenopausal females with regular menstrual cycle and aged between 15-45 years. Blood samples were collected at follicular and luteal phases of their menstrual cycle for assay of Thyroid indices (FT3, FT4 and TSH) and Reproductive indices (FSH, LH, Estrogen, Progesterone, Prolactin and Testosterone) using ELISA method.

Results: The result showed significantly higher FSH and LH but significantly lower progesterone (prog) and estrogen (E2) in the test females compared to control females at both phases of menstrual cycle (P<0.05). There was significantly lower FT3 but significantly higher TSH value in Symptomatic HIV females (P<0.05). FSH, LH and TSH values were significantly lowered while prog and FT3 were significantly higher in Symptomatic HIV on ART compared to Symptomatic HIV females (P<0.05). FT3, FT4, Prog and E2 were inversely correlated while FSH and LH were positively correlated with duration of HIV infection in HIV females (P<0.05 respectively). There was a direct correlation between CD4+ count and FT3 while inverse correlation was found between CD4+ count and TSH levels (P<0.05).

Discussion: The present study demonstrated hypothyroidism with a significant degree of primary hypogonadism in Symptomatic HIV infected females at both follicular and luteal phases of menstrual cycle which tends to normalize on treatments.

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