Adaptation of MRNA Structure to Control Protein Folding

Overview

Journal RNA Biol

Specialty Molecular Biology

Date 2017 Jul 20

PMID 28722509

Citations 20

Authors

Guilhem Faure

Aleksey Y Ogurtsov

Svetlana A Shabalina

Eugene V Koonin

Affiliations

Soon will be listed here.

Abstract

Comparison of mRNA and protein structures shows that highly structured mRNAs typically encode compact protein domains suggesting that mRNA structure controls protein folding. This function is apparently performed by distinct structural elements in the mRNA, which implies 'fine tuning' of mRNA structure under selection for optimal protein folding. We find that, during evolution, changes in the mRNA folding energy follow amino acid replacements, reinforcing the notion of an intimate connection between the structures of a mRNA and the protein it encodes, and the double encoding of protein sequence and folding in the mRNA.

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