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Microbial Biofilms and the Human Intestinal Microbiome

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Date 2017 Jul 20
PMID 28721229
Citations 64
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Abstract

Since early life we are colonised by a myriad of microbes that make up our microbiome. This colonisation process starts at birth or even before, when the virtually sterile baby encounters new microbial environments. It is likely that at this time or at later moments in life, microbial communities are met that have high-level structures with a temporal and spatial organisation, termed biofilms. This perspective will focus on these biofilms and the microbes in the intestinal tract as these are the most numerous in the human body, are found in luminal and mucosal locations, and have a great impact on human health and disease.

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References
1.
Macfarlane S, Dillon J . Microbial biofilms in the human gastrointestinal tract. J Appl Microbiol. 2007; 102(5):1187-96. DOI: 10.1111/j.1365-2672.2007.03287.x. View

2.
Sommer F, Backhed F . The gut microbiota--masters of host development and physiology. Nat Rev Microbiol. 2013; 11(4):227-38. DOI: 10.1038/nrmicro2974. View

3.
Qin J, Li R, Raes J, Arumugam M, Burgdorf K, Manichanh C . A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010; 464(7285):59-65. PMC: 3779803. DOI: 10.1038/nature08821. View

4.
Zarco M, Vess T, Ginsburg G . The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral Dis. 2011; 18(2):109-20. DOI: 10.1111/j.1601-0825.2011.01851.x. View

5.
Belzer C, de Vos W . Microbes inside--from diversity to function: the case of Akkermansia. ISME J. 2012; 6(8):1449-58. PMC: 3401025. DOI: 10.1038/ismej.2012.6. View