The Plasma Concentration of MUC5B Is Associated with Clinical Outcomes in Paraquat-poisoned Patients

Overview

Journal Am J Respir Crit Care Med

Specialty Critical Care

Date 2017 Jul 19

PMID 28719757

Citations 7

Authors

Andrew A Monte

Hao Sun

Anna Malin Rapp-Olsson

Fahim Mohamed

Indika Gawarammana

Nicholas A Buckley

Christopher M Evans

Ivana V Yang

David A Schwartz

Affiliations

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Citing Articles

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Development and validation of a sensitive and high throughput UPLC-MS/MS method for determination of paraquat and diquat in human plasma and urine: application to poisoning cases at emergency departments of hospitals.

Mao Z, Yu Y, Sun H, Xie W, Zhao H, Jiang Q Forensic Toxicol. 2022; 40(1):102-110.

PMID: 36454496 DOI: 10.1007/s11419-021-00603-9.

Paraquat is an agonist of STIM1 and increases intracellular calcium levels.

Yang W, Tian R, Zhu Y, Huang P, Ma X, Meng X Commun Biol. 2022; 5(1):1151.

PMID: 36310238 PMC: 9618025. DOI: 10.1038/s42003-022-04130-0.

Respiratory MUC5B disproportion is involved in severe community-acquired pneumonia.

Fan L, Lu Y, Wang Y, Zhang X, Wu Y, Sun H BMC Pulm Med. 2022; 22(1):90.

PMID: 35292003 PMC: 8922065. DOI: 10.1186/s12890-022-01870-x.

The MUC5B Mucin Is Involved in Paraquat-Induced Lung Inflammation.

Sun H, Jiang Y, Song Y, Zhang X, Wang J, Zhang J Oxid Med Cell Longev. 2020; 2020:7028947.

PMID: 32724493 PMC: 7381986. DOI: 10.1155/2020/7028947.

References

Nakano Y, Yang I, Walts A, Watson A, Helling B, Fletcher A . MUC5B Promoter Variant rs35705950 Affects MUC5B Expression in the Distal Airways in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016; 193(4):464-6. PMC: 4803086. DOI: 10.1164/rccm.201509-1872LE. View

Gunawardena G, Roberts D, Buckley N . Randomized control trial of immunosuppression in paraquat poisoning. Crit Care Med. 2007; 35(1):330-1. DOI: 10.1097/01.CCM.0000251817.82117.7D. View

Roy M, Livraghi-Butrico A, Fletcher A, McElwee M, Evans S, Boerner R . Muc5b is required for airway defence. Nature. 2013; 505(7483):412-6. PMC: 4001806. DOI: 10.1038/nature12807. View

Wunnapuk K, Mohammed F, Gawarammana I, Liu X, Verbeeck R, Buckley N . Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach. Br J Clin Pharmacol. 2014; 78(4):855-66. PMC: 4239979. DOI: 10.1111/bcp.12389. View

Gawarammana I, Buckley N . Medical management of paraquat ingestion. Br J Clin Pharmacol. 2011; 72(5):745-57. PMC: 3243009. DOI: 10.1111/j.1365-2125.2011.04026.x. View