Neuronal Activity in Ontogeny and Oncology

Overview

Journal Trends Cancer

Publisher Cell Press

Specialty Oncology

Date 2017 Jul 19

PMID 28718448

Citations 55

Authors

Humsa Venkatesh

Michelle Monje

Affiliations

Soon will be listed here.

Abstract

The nervous system plays a central role in regulating the stem cell niche in many organs, and thereby pivotally modulates development, homeostasis, and plasticity. A similarly powerful role for neural regulation of the cancer microenvironment is emerging. Neurons promote the growth of cancers of the brain, skin, prostate, pancreas, and stomach. Parallel mechanisms shared in development and cancer suggest that neural modulation of the tumor microenvironment may prove a universal theme, although the mechanistic details of such modulation remain to be discovered for many malignancies. We review here what is known about the influences of active neurons on stem cell and cancer microenvironments across a broad range of tissues, and we discuss emerging principles of neural regulation of development and cancer.

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