Mechanism of Action for RTMS: A Working Hypothesis Based on Animal Studies

Overview

Journal Front Physiol

Date 2017 Jul 18

PMID 28713286

Citations 20

Authors

Thangavelu Soundara Rajan

Maria F M Ghilardi

Hoau-Yan Wang

Emanuela Mazzon

Placido Bramanti

Domenico Restivo

Angelo Quartarone

Affiliations

Soon will be listed here.

Abstract

Experiments in rodents have elucidated some of the molecular mechanisms underlying repetitive transcranial magnetic stimulation (rTMS). These studies may be useful in a translational perspective so that future TMS studies in rodents can closely match human TMS protocols designed for therapeutic purposes. In the present work we will review the effects of rTMS on glutamate neurotransmission which in turn induce persistent changes in synaptic activity. In particular, we will focus on the role of NMDA and non-NMDA transmission and on the permissive role of BDNF-TrKB interaction in the rTMS induced after-effects.

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