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Correlation Between In-vitro Microsomal Enzyme Activity and Whole Organ Hepatic Elimination Kinetics: Analysis with a Dispersion Model

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Specialties Pharmacology
Pharmacy
Date 1986 Mar 1
PMID 2871151
Citations 26
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Abstract

A new model, the dispersion model of hepatic elimination, is applied to the correlation between in-vitro microsomal data and corresponding rat isolated perfused liver data for a number of drugs reported in the literature, whose extraction ratio varies over the range of 0.01 to 0.995. The dispersion model described the data better than either the 'well-stirred' model or the 'parallel-tube' model, two other widely used models of hepatic elimination. The experimental data support the concept that elimination of solutes is affected by is a considerable dispersion on passage through the liver.

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