Objective:
To determine the effectiveness of a novel interdisciplinary treatment compared with usual care on weight loss in overweight and obese adult volunteers.
Design:
Single blinded controlled trial. Participants randomly assigned to usual care (C, general guideline-based diet and exercise advice), intervention (I, interdisciplinary protocol) or intervention + a healthy food supplement (30 g walnuts/day) (IW).
Setting:
Community based study, Illawarra region, south of Sydney, Australia.
Participants:
Generally well volunteer adult residents, 25-54 years, body mass index (BMI) 25-40kg/m were eligible. At baseline 439 were assessed, 377 were randomised, 298 completed the 3-month intensive phase and 178 completed the 12-month follow-up.
Interventions:
Treatment was provided at clinic visits intensively (0 months, 1 month, 2 months, 3 months) then quarterly to 12 months. Support phone calls were quarterly. All participants underwent blinded assessments for diet, exercise and psychological status.
Primary And Secondary Measures:
The primary outcome was difference in weight loss between baseline and 12 months (clinically relevant target 5% loss). Secondary outcomes were changes in blood pressure, fasting blood glucose and lipids, and changes in diet, exercise and psychological parameters.
Results:
At 12 months, differences in weight loss were identified (p<0.001). The I group lost more than controls at 3 months (91.11 (92.23,90.00), p<0.05) and the IW more than controls at 3 months (91.25 (92.35,90.15), p<0.05) and 6 months (92.20 (93.90,90.49), p<0.01). The proportion achieving 5% weight loss was significantly different at 3 months, 6 months and 9 months (p=0.04, p=0.03, p=0.03), due to fewer controls on target at 3 months, 6 months and 9 months and more IW participants at 6 months. Reductions in secondary outcomes (systolic blood pressure, blood glucose/lipid parameters and lifestyle measures) followed the pattern of weight loss.
Conclusions:
An interdisciplinary intervention produced greater and more clinically significant and sustained weight loss compared with usual care. The intensive phase was sufficient to reach clinically relevant targets, but long-term management plans may be required.
Trial Registration Number:
ANZCTRN 12614000581662; Post-results.
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A comparison between weight loss outcomes with anti-obesity medications before and during Covid-19 pandemic at a tertiary weight management center.
Rosa A, Ghusn W, Sacoto D, Campos A, Cifuentes L, Feris F
Obes Pillars. 2023; 4:100046.
PMID: 37990666
PMC: 9714128.
DOI: 10.1016/j.obpill.2022.100046.
Tree Nut and Peanut Consumption and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Houston L, Probst Y, Chandra Singh M, Neale E
Adv Nutr. 2023; 14(5):1029-1049.
PMID: 37149262
PMC: 10509427.
DOI: 10.1016/j.advnut.2023.05.004.
Novel Lines of Research on the Environmental and Human Health Impacts of Nut Consumption.
Tapsell L, Sabate J, Martinez R, Llavanera M, Neale E, Salas-Huetos A
Nutrients. 2023; 15(4).
PMID: 36839312
PMC: 9964796.
DOI: 10.3390/nu15040955.
Identifying usual food choices with avocados in a clinical trial cohort of overweight and obese adults in Australia.
Guan V, Neale E, Probst Y
PLoS One. 2023; 18(1):e0279567.
PMID: 36701374
PMC: 9879481.
DOI: 10.1371/journal.pone.0279567.
Weight regain and mental health outcomes following behavioural weight management programmes: A systematic review with meta-analyses.
Theodoulou A, Hartmann-Boyce J, Gorenberg J, Oke J, Butler A, Bastounis A
Clin Obes. 2023; 13(3):e12575.
PMID: 36623842
PMC: 10909518.
DOI: 10.1111/cob.12575.
Walnut consumption and health outcomes with public health relevance-a systematic review of cohort studies and randomized controlled trials published from 2017 to present.
Lockyer S, de la Hunty A, Steenson S, Spiro A, Stanner S
Nutr Rev. 2022; 81(1):26-54.
PMID: 35912883
PMC: 9732668.
DOI: 10.1093/nutrit/nuac040.
Acceptability, Usability and Weight Loss Outcomes in a Randomized Cross-Over Study of Commercially Available Portion Size Tools in an Overweight South Asian Community.
Ellahi B, Aitken A, Dikmen D, Seyhan-Erdogan B, Makda M, Razaq R
Int J Environ Res Public Health. 2022; 19(13).
PMID: 35805371
PMC: 9266172.
DOI: 10.3390/ijerph19137714.
Effect of ideal protein versus low-fat diet for weight loss: A randomized controlled trial.
Fernandez C, Potts K, Bazzano L
Obes Sci Pract. 2022; 8(3):299-307.
PMID: 35664249
PMC: 9159558.
DOI: 10.1002/osp4.567.
A systematic review of inequalities in the uptake of, adherence to, and effectiveness of behavioral weight management interventions in adults.
Birch J, Jones R, Mueller J, McDonald M, Richards R, Kelly M
Obes Rev. 2022; 23(6):e13438.
PMID: 35243743
PMC: 9285567.
DOI: 10.1111/obr.13438.
Physical activity, diet, and weight loss in patients recruited from primary care settings: An update on obesity management interventions.
de Lannoy L, Cowan T, Fernandez A, Ross R
Obes Sci Pract. 2021; 7(5):619-628.
PMID: 34631139
PMC: 8488444.
DOI: 10.1002/osp4.514.
Are fatty nuts a weighty concern? A systematic review and meta-analysis and dose-response meta-regression of prospective cohorts and randomized controlled trials.
Nishi S, Viguiliouk E, Mejia S, Kendall C, Bazinet R, Hanley A
Obes Rev. 2021; 22(11):e13330.
PMID: 34494363
PMC: 9285885.
DOI: 10.1111/obr.13330.
The Relationship of Tree Nuts and Peanuts with Adiposity Parameters: A Systematic Review and Network Meta-Analysis.
Fernandez-Rodriguez R, Mesas A, Garrido-Miguel M, Martinez-Ortega I, Jimenez-Lopez E, Martinez-Vizcaino V
Nutrients. 2021; 13(7).
PMID: 34208812
PMC: 8308485.
DOI: 10.3390/nu13072251.
Walnut intake, cognitive outcomes and risk factors: a systematic review and meta-analysis.
Cahoon D, Shertukde S, Avendano E, Tanprasertsuk J, Scott T, Johnson E
Ann Med. 2021; 53(1):971-997.
PMID: 34132152
PMC: 8211141.
DOI: 10.1080/07853890.2021.1925955.
The impact of adult behavioural weight management interventions on mental health: A systematic review and meta-analysis.
Jones R, Lawlor E, Birch J, Patel M, Werneck A, Hoare E
Obes Rev. 2020; 22(4):e13150.
PMID: 33103340
PMC: 7116866.
DOI: 10.1111/obr.13150.
Identifying Usual Food Choice Combinations With Walnuts: Analysis of a 2005-2015 Clinical Trial Cohort of Overweight and Obese Adults.
Guan V, Neale E, Tapsell L, Probst Y
Front Nutr. 2020; 7:149.
PMID: 33072791
PMC: 7540216.
DOI: 10.3389/fnut.2020.00149.
Association between shared medical appointments and weight loss outcomes and anti-obesity medication use in patients with obesity.
Shibuya K, Ji X, Pfoh E, Milinovich A, Weng W, Bauman J
Obes Sci Pract. 2020; 6(3):247-254.
PMID: 32523713
PMC: 7278906.
DOI: 10.1002/osp4.406.
Weight Management Programme for Overweight and Obese Adults in Ningbo, China: A Feasibility Pre- and Post-intervention Study.
Xu M, Chattopadhyay K, Li J, Rai N, Chen Y, Hu F
Front Public Health. 2020; 7:388.
PMID: 31921752
PMC: 6930184.
DOI: 10.3389/fpubh.2019.00388.
Does Nut Consumption Reduce Mortality and/or Risk of Cardiometabolic Disease? An Updated Review Based on Meta-Analyses.
Kim Y, Keogh J, Clifton P
Int J Environ Res Public Health. 2019; 16(24).
PMID: 31817639
PMC: 6950421.
DOI: 10.3390/ijerph16244957.
Intensity and duration of lifestyle interventions for long-term weight loss and association with mortality: a meta-analysis of randomised trials.
Singh N, Stewart R, Benatar J
BMJ Open. 2019; 9(8):e029966.
PMID: 31427335
PMC: 6701694.
DOI: 10.1136/bmjopen-2019-029966.
Evaluation of the dietary intake data coding process in a clinical setting: Implications for research practice.
Guan V, Probst Y, Neale E, Tapsell L
PLoS One. 2019; 14(8):e0221047.
PMID: 31404088
PMC: 6690518.
DOI: 10.1371/journal.pone.0221047.