How to Design Efficient Cluster Randomised Trials

Overview

Journal BMJ

Specialty General Medicine

Date 2017 Jul 16

PMID 28710062

Citations 91

Authors

K Hemming

S Eldridge

G Forbes

C Weijer

M Taljaard

Affiliations

Soon will be listed here.

Citing Articles

No evidence for decision fatigue using large-scale field data from healthcare.

Andersson D, Lindberg M, Tinghog G, Persson E Commun Psychol. 2025; 3(1):33.

PMID: 40011733 PMC: 11865449. DOI: 10.1038/s44271-025-00207-8.

Establishing best practices in large language model research: an application to repeat prompting.

Gallo R, Baiocchi M, Savage T, Chen J J Am Med Inform Assoc. 2024; 32(2):386-390.

PMID: 39656836 PMC: 11756642. DOI: 10.1093/jamia/ocae294.

Randomized Trials Using Provincial Health Numbers for Group Assignment.

Garg A, Dixon S, Ma C, Basile E, Luo B, De Melo M Can J Kidney Health Dis. 2024; 11:20543581241304510.

PMID: 39650083 PMC: 11624533. DOI: 10.1177/20543581241304510.

Effect of community health education on mothers' knowledge of obstetric danger signs and birth preparedness and complication readiness practices in southern Ethiopia: A cluster randomized controlled trial.

Yoseph A, Teklesilasie W, Guillen-Grima F, Astatkie A PLoS One. 2024; 19(11):e0312267.

PMID: 39602439 PMC: 11602057. DOI: 10.1371/journal.pone.0312267.

Becoming Active in Beating osteoarthritiS: study protocol of a randomised controlled trial on the effectiveness of an information campaign in improving the management of osteoarthritis and quality of care in general practices in the Netherlands.

Oomen J, Schers H, Das E, Koeter S, van den Ende C, Assendelft W BMJ Open. 2024; 14(11):e083496.

PMID: 39572089 PMC: 11580255. DOI: 10.1136/bmjopen-2023-083496.

References

Peto R, Collins R, Gray R . Large-scale randomized evidence: large, simple trials and overviews of trials. J Clin Epidemiol. 1995; 48(1):23-40. DOI: 10.1016/0895-4356(94)00150-o. View

Campbell M, Donner A, Klar N . Developments in cluster randomized trials and Statistics in Medicine. Stat Med. 2006; 26(1):2-19. DOI: 10.1002/sim.2731. View

Donner A, Klar N . Statistical considerations in the design and analysis of community intervention trials. J Clin Epidemiol. 1996; 49(4):435-9. DOI: 10.1016/0895-4356(95)00511-0. View

Campbell M, Mollison J, Grimshaw J . Cluster trials in implementation research: estimation of intracluster correlation coefficients and sample size. Stat Med. 2001; 20(3):391-9. DOI: 10.1002/1097-0258(20010215)20:3<391::aid-sim800>3.0.co;2-z. View

Angus D . Fusing Randomized Trials With Big Data: The Key to Self-learning Health Care Systems?. JAMA. 2015; 314(8):767-8. DOI: 10.1001/jama.2015.7762. View

Hemming K, Girling A, Sitch A, Marsh J, Lilford R . Sample size calculations for cluster randomised controlled trials with a fixed number of clusters. BMC Med Res Methodol. 2011; 11:102. PMC: 3149598. DOI: 10.1186/1471-2288-11-102. View

Carter B . Cluster size variability and imbalance in cluster randomized controlled trials. Stat Med. 2010; 29(29):2984-93. DOI: 10.1002/sim.4050. View

Hooper R, Bourke L . Cluster randomised trials with repeated cross sections: alternatives to parallel group designs. BMJ. 2015; 350:h2925. DOI: 10.1136/bmj.h2925. View

Taljaard M, Teerenstra S, Ivers N, Fergusson D . Substantial risks associated with few clusters in cluster randomized and stepped wedge designs. Clin Trials. 2016; 13(4):459-63. DOI: 10.1177/1740774516634316. View

10.

Guittet L, Giraudeau B, Ravaud P . A priori postulated and real power in cluster randomized trials: mind the gap. BMC Med Res Methodol. 2005; 5:25. PMC: 1190183. DOI: 10.1186/1471-2288-5-25. View

11.

Eldridge S, Costelloe C, Kahan B, Lancaster G, Kerry S . How big should the pilot study for my cluster randomised trial be?. Stat Methods Med Res. 2015; 25(3):1039-56. DOI: 10.1177/0962280215588242. View

12.

Bland J . The tyranny of power: is there a better way to calculate sample size?. BMJ. 2009; 339:b3985. DOI: 10.1136/bmj.b3985. View