Beta Adrenergic Influence on Oesophageal Peristalsis in Man

Overview

Journal Gut

Specialty Gastroenterology

Date 1986 Mar 1

PMID 2870956

Citations 11

Authors

E Lyrenas

H Abrahamsson

Affiliations

Soon will be listed here.

Abstract

The effects of the beta-1 adrenergic agonist prenalterol and the beta-2 adrenergic agonist terbutaline on oesophageal peristalsis were studied in nine healthy volunteers with pressures recorded in the proximal, middle, and distal oesophagus. Two doses of the agonists were given after pretreatment with placebo, propranolol, or metoprolol in a double blind randomised fashion. Terbutaline 0.25 +/- 0.25 mg iv decreased peristaltic pressure in middle oesophagus from 8.1 +/- 1.1 to 5.1 +/- 0.8 kPa (p less than 0.01) and in the distal oesophagus from 9.5 +/- 1.0 to 4.7 +/- 0.6 kPa (p less than 0.001). Peristaltic velocity was decreased in the distal oesophagus after terbutaline from 3.3 +/- 0.2 cm/sec to 2.9 +/- 0.2 cm/sec (p less than 0.05). Prenalterol 1 mg iv was followed by a decrease of peristaltic pressure in the middle oesophagus from 10.2 +/- 1.3 to 7.7 +/- 1.1 kPa (p less than 0.01) and a decrease of peristaltic velocity in upper oesophagus from 3.6 +/- 0.2 to 3.3 +/- 0.1 cm/sec (p less than 0.05) while no significant changes were seen in the distal oesophagus. Pretreatment with the beta-1 blocker metoprolol 15 mg iv blocked the effects of prenalterol 1 mg iv but not the effects of terbutaline. Propranolol 10 mg iv blocked the effects of terbutaline on peristaltic pressure. After metoprolol infusion mean distal peristaltic amplitude was 11.9 +/- 0.8 kPa compared with 8.5 +/- 1.2 kPa after placebo (p less than 0.01). It is concluded that both beta-1 and beta-2 adrenoceptor stimulation significantly decrease oesophageal peristaltic pressure in man. The body of the oesophagus seems to be under beta adrenergic inhibitory influence under physiological conditions.

Citing Articles

Gastroesophageal Reflux Disease Is Not Associated With Jackhammer Esophagus: A Case-control Study.

Woo M, Liu A, Wilsack L, Li D, Gupta M, Nasser Y J Neurogastroenterol Motil. 2020; 26(2):224-231.

PMID: 32235029 PMC: 7176498. DOI: 10.5056/jnm19096.

Gastric electrical stimulation significantly increases canine lower esophageal sphincter pressure.

Xing J, Felsher J, Brody F, Soffer E Dig Dis Sci. 2005; 50(8):1481-7.

PMID: 16110840 DOI: 10.1007/s10620-005-2866-4.

Beta-adrenoreceptor agonists for diffuse esophageal spasm.

Okamura S, Oshimoto H, Sakamoto T, Kusano M, Sekiguchi T, Mori M J Gastroenterol. 2002; 37(3):229-30.

PMID: 11931538 DOI: 10.1007/s005350200026.

Functional assessment of beta adrenoceptor subtypes in human colonic circular and longitudinal (taenia coli) smooth muscle.

Manara L, Croci T, Aureggi G, Guagnini F, Maffrand J, Le Fur G Gut. 2000; 47(3):337-42.

PMID: 10940268 PMC: 1728040. DOI: 10.1136/gut.47.3.337.

Symptomatic gastroesophageal reflux in acutely hospitalized patients.

Newton M, Kamm M, Quigley T, Burnham W Dig Dis Sci. 1999; 44(1):140-8.

PMID: 9952235 DOI: 10.1023/a:1026618620480.

References

JACOBOWITZ D . Histochemical studies of the autonomic innervation of the gut. J Pharmacol Exp Ther. 1965; 149(3):358-64. View

NORBERG K . ADRENERGIC INNERVATION OF THE INTESTINAL WALL STUDIED BY FLUORESCENCE MICROSCOPY. Int J Neuropharmacol. 1964; 3:379-82. DOI: 10.1016/0028-3908(64)90067-x. View

Paton W, Vizi E . The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea-pig ileum longitudinal muscle strip. Br J Pharmacol. 1969; 35(1):10-28. PMC: 1703074. DOI: 10.1111/j.1476-5381.1969.tb07964.x. View

Zfass A, Prince R, Allen F, Farrar J . Inhibitory beta adrenergic receptors in the human distal esophagus. Am J Dig Dis. 1970; 15(4):303-10. DOI: 10.1007/BF02239282. View

KOSTERLITZ H, Lydon R, Watt A . The effects of adrenaline, noradrenaline and isoprenaline on inhibitory alpha- and beta-adrenoceptors in the longitudinal muscle of the guinea-pig ileum. Br J Pharmacol. 1970; 39(2):398-413. PMC: 1702841. DOI: 10.1111/j.1476-5381.1970.tb12903.x. View

DiMarino A, Cohen S . The adrenergic control of lower esophageal sphincter function. An experimental model of denervation supersensitivity. J Clin Invest. 1973; 52(9):2264-71. PMC: 333029. DOI: 10.1172/JCI107413. View

Cohen S, Green F . Force-velocity characteristics of esophageal muscle: effect of acetylcholine and norepinephrine. Am J Physiol. 1974; 226(5):1250-6. DOI: 10.1152/ajplegacy.1974.226.5.1250. View

Cohen S . Force velocity characteristics of oesophageal muscle: interaction of isoproterenol and calcium. Eur J Clin Invest. 1975; 5(3):259-65. DOI: 10.1111/j.1365-2362.1975.tb00453.x. View

Goyal R, Rattan S . Genesis of basal sphincter pressure: effect of tetrodotoxin on lower esophageal sphincter pressure in opossum in vivo. Gastroenterology. 1976; 71(1):62-7. View

10.

Gillespie J, KHOYI M . The site and receptors responsible for the inhibition by sympathetic nerves of intestinal smooth muscle and its parasympathetic motor nerves. J Physiol. 1977; 267(3):767-89. PMC: 1283639. DOI: 10.1113/jphysiol.1977.sp011837. View

11.

Carlsson E, Dahlof C, Hedberg A, Persson H, Tangstrand B . Differentiation of cardiac chronotropic and inotropic effects of beta-adrenoceptor agonists. Naunyn Schmiedebergs Arch Pharmacol. 1977; 300(2):101-5. DOI: 10.1007/BF00505039. View

12.

Ronn O, Fellenius E, Graffner C, Johnsson G, Lundborg P, Svensson L . Metabolic and haemodynamic effects and pharmacokinetics of a new selective beta 1-adrenoceptor agonist, prenalterol, in man. Eur J Clin Pharmacol. 1980; 17(2):81-6. DOI: 10.1007/BF00562614. View

13.

Dodds W, Dent J, Hogan W, Arndorfer R . Effect of atropine on esophageal motor function in humans. Am J Physiol. 1981; 240(4):G290-6. DOI: 10.1152/ajpgi.1981.240.4.G290. View

14.

Ronn O, Johnsson G, Lundborg P . Interaction in healthy volunteers between prenalterol, a selective beta 1-adrenoceptor agonist, and metoprolol or propranolol. J Cardiovasc Pharmacol. 1981; 3(3):477-84. DOI: 10.1097/00005344-198105000-00007. View

15.

Phaosawasdi K, Malmud L, Tolin R, Stelzer F, Applegate G, Fisher R . Cholinergic effects on esophageal transit and clearance. Gastroenterology. 1981; 81(5):915-20. View

16.

Ek B, Lundgren B . Characterization of the beta-adrenergic inhibition of motility in cat colon strips. Eur J Pharmacol. 1982; 77(1):25-31. DOI: 10.1016/0014-2999(82)90530-1. View

17.

Bengtsson B, Fagerstrom P . Extrapulmonary effects of terbutaline during prolonged administration. Clin Pharmacol Ther. 1982; 31(6):726-32. DOI: 10.1038/clpt.1982.102. View

18.

Apperley G, Drew G, Sullivan A . Prenalterol is an agonist at beta 2- as well as at beta 1-adrenoceptors. Eur J Pharmacol. 1982; 81(4):659-63. DOI: 10.1016/0014-2999(82)90356-9. View

19.

Dimarino Jr A, Cohen S . Effect of an oral beta2-adrenergic agonist on lower esophageal sphincter pressure in normals and in patients with achalasia. Dig Dis Sci. 1982; 27(12):1063-6. DOI: 10.1007/BF01391441. View

20.

Nelson H . Gastroesophageal reflux and pulmonary disease. J Allergy Clin Immunol. 1984; 73(5 Pt 1):547-56. DOI: 10.1016/0091-6749(84)90509-8. View