The Influence of Simulated Microgravity on Proliferation and Apoptosis in U251 Glioma Cells

Overview

Journal In Vitro Cell Dev Biol Anim

Publisher Springer

Specialties Biology
Cell Biology

Date 2017 Jul 15

PMID 28707224

Citations 11

Authors

Jiao Zhao

He Ma

Leitao Wu

Liang Cao

Qianqian Yang

Haijun Dong

Zongren Wang

Jing Ma

Zhen Li

Affiliations

Soon will be listed here.

Abstract

Several studies have indicated that microgravity can influence cellular progression, proliferation, and apoptosis in tumor cell lines. In this study, we observed that simulated microgravity inhibited proliferation and induced apoptosis in U251 malignant glioma (U251MG) cells. Furthermore, expression of the apoptosis-associated proteins, p21 and insulin-like growth factor binding protein-2 (IGFBP-2), was upregulated and downregulated, respectively, following exposure to simulated microgravity. These findings indicate that simulated microgravity inhibits proliferation while inducing apoptosis of U251MG cells. The associated effects appear to be mediated by inhibition of IGFBP-2 expression and stimulation of p21 expression. This suggests that simulated microgravity might represent a promising method to discover new targets for glioma therapeutic strategy.

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