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Fever and Pancytopenia in a Liver Transplant Recipient: Going Against the Rules of Occam's Razor

Overview
Publisher Wolters Kluwer
Specialty General Surgery
Date 2017 Jul 15
PMID 28706972
Authors
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Abstract

The syndrome of fever and pancytopenia is not infrequently encountered postliver transplant, and a broad differential list of infectious and noninfectious aetiologies can be invoked. A transplant patient is susceptible to more than 1 opportunistic infection or disease process. We described the diagnostic conundrums in managing our patient who ran a complex protracted course postliver transplant. He was diagnosed to have both disseminated tuberculosis and graft-versus-host disease, a rare complication after solid organ transplantation.

References
1.
Kohler S, Pascher A, Junge G, Sauer I, Nagy M, Schonemann C . Graft versus host disease after liver transplantation - a single center experience and review of literature. Transpl Int. 2008; 21(5):441-51. DOI: 10.1111/j.1432-2277.2007.00625.x. View

2.
Aguado J, Torre-Cisneros J, Fortun J, Benito N, Meije Y, Doblas A . Tuberculosis in solid-organ transplant recipients: consensus statement of the group for the study of infection in transplant recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology. Clin Infect Dis. 2009; 48(9):1276-84. DOI: 10.1086/597590. View

3.
Chan E, Larson A, Gernsheimer T, Kowdley K, Carithers Jr R, Reyes J . Recipient and donor factors influence the incidence of graft-vs.-host disease in liver transplant patients. Liver Transpl. 2007; 13(4):516-22. DOI: 10.1002/lt.21082. View

4.
Ip M, Yuen K, Woo P, Luk W, Tsang K, Lam W . Risk factors for pulmonary tuberculosis in bone marrow transplant recipients. Am J Respir Crit Care Med. 1998; 158(4):1173-7. DOI: 10.1164/ajrccm.158.4.9712072. View

5.
Akbulut S, Yilmaz M, Yilmaz S . Graft-versus-host disease after liver transplantation: a comprehensive literature review. World J Gastroenterol. 2012; 18(37):5240-8. PMC: 3468857. DOI: 10.3748/wjg.v18.i37.5240. View