The Anecdote of Viral Etiopathogenia in Ameloblastoma and Odontogenic Keratocyst: Why Don't We Let It Go?

Overview

Journal J Oral Biol Craniofac Res

Publisher Elsevier

Date 2017 Jul 15

PMID 28706783

Citations 2

Authors

Bacem A E O Khalele

Affiliations

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Abstract

Background: Ameloblastoma (AM) and odontogenic Keratocyst (OKC) are destructive odontogenic lesions of the gnathion. Although their exact pathogeneses are not yet totally understood, the viral etiopathogenesis in AM and KCOT has been proposed. True to syndromic keratocystic odontogenic tumor (sKCOT) and non-syndromic OKC is the high recurrence rate.

Objectives: Given that shared pathways trailed by AM and by sKCOT/OKC have been suggested, this study, however, contrasts the expression of AM and OKC for viral antibodies.

Method: A total of archival 80 paraffin blocks of cases of parakeratinized odontogenic keratocyst (non-syndromic KCOTs) and of ameloblastomas (n = 40 for each) were included in this study to be sectioned and stained for two immunohistochemical markers: anti-human papillomavirus and Epstein-Barr virus-encoded latent membrane protein.

Results: All the submitted cases of AM and parakeratinized OKC were negative for both markers: anti-HPV and anti-LMP-1.

Conclusions: Although results could have been biased, given the same ethnic group and territory examined in this study, all cases were negative for both markers. Therefore, the viral contribution to the etiopathogenesis in AM and OKC could not be established in this study.

Citing Articles

Low Detection of High-risk Human Papilloma Virus in Individuals with Ameloblastoma in a Tertiary Hospital in Lagos, Nigeria.

Akinshipo A, Salu O, Oluwarotimi C, Anyanwu R, Aforka E, Effiom O Ann Afr Med. 2024; 23(3):406-414.

PMID: 39034566 PMC: 11364336. DOI: 10.4103/aam.aam_102_23.

Arenavirus as a potential etiological agent of odontogenic tumours in humans.

de Feo M, De Leo C, Romeo U, Muti P, Blandino G, Di Agostino S J Exp Clin Cancer Res. 2020; 39(1):34.

PMID: 32041643 PMC: 7011367. DOI: 10.1186/s13046-020-1540-1.

References

Migaldi M, Pecorari M, Rossi G, Maiorana A, Bettelli S, Tamassia M . Does HPV play a role in the etiopathogenesis of ameloblastoma? An immunohistochemical, in situ hybridization and polymerase chain reaction study of 18 cases using laser capture microdissection. Mod Pathol. 2004; 18(2):283-9. DOI: 10.1038/modpathol.3800241. View

Gurgel C, Buim M, Carvalho K, Sales C, Reis M, de Souza R . Transcriptional profiles of SHH pathway genes in keratocystic odontogenic tumor and ameloblastoma. J Oral Pathol Med. 2014; 43(8):619-26. DOI: 10.1111/jop.12180. View

Ninomiya T, Kubota Y, Koji T, Shirasuna K . Marsupialization inhibits interleukin-1alpha expression and epithelial cell proliferation in odontogenic keratocysts. J Oral Pathol Med. 2002; 31(9):526-33. DOI: 10.1034/j.1600-0714.2002.00029.x. View

Myoung H, Hong S, Hong S, Lee J, Lim C, Choung P . Odontogenic keratocyst: Review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 91(3):328-33. DOI: 10.1067/moe.2001.113109. View

Khojasteh A, Khodayari A, Rahimi F, Ghaderian M, Jafarian M, Nayebi A . Hypermethylation of p16 tumor-suppressor gene in ameloblastic carcinoma, ameloblastoma, and dental follicles. J Oral Maxillofac Surg. 2012; 71(1):62-5. DOI: 10.1016/j.joms.2012.04.033. View

Li B, Wan Z, Huang G, Huang Z, Zhang X, Liao D . Mitogen- and stress-activated Kinase 1 mediates Epstein-Barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of Fra-1 and c-Jun genes. BMC Cancer. 2015; 15:390. PMC: 4434874. DOI: 10.1186/s12885-015-1398-3. View

Neuman A, Montague L, Cohen D, Islam N, Bhattacharyya I . Report of Two Cases of Combined Odontogenic Tumors: Ameloblastoma with Odontogenic Keratocyst and Ameloblastic Fibroma with Calcifying Odontogenic Cyst. Head Neck Pathol. 2015; 9(3):417-20. PMC: 4542788. DOI: 10.1007/s12105-014-0601-1. View

Verduin L, Bishop J, Mills S . Gnathic and peripheral ameloblastomas lack human papillomavirus DNA. Ann Diagn Pathol. 2015; 19(5):306-9. DOI: 10.1016/j.anndiagpath.2015.06.006. View

Sharif F, Oliver R, Sweet C, Sharif M . Interventions for the treatment of keratocystic odontogenic tumours. Cochrane Database Syst Rev. 2015; (11):CD008464. PMC: 7173719. DOI: 10.1002/14651858.CD008464.pub3. View

10.

Agaram N, Collins B, Barnes L, Lomago D, Aldeeb D, Swalsky P . Molecular analysis to demonstrate that odontogenic keratocysts are neoplastic. Arch Pathol Lab Med. 2004; 128(3):313-7. DOI: 10.5858/2004-128-313-MATDTO. View

11.

Crusius K, Rodriguez I, Alonso A . The human papillomavirus type 16 E5 protein modulates ERK1/2 and p38 MAP kinase activation by an EGFR-independent process in stressed human keratinocytes. Virus Genes. 2000; 20(1):65-9. DOI: 10.1023/a:1008112207824. View

12.

Ren C, Amm H, DeVilliers P, Wu Y, Deatherage J, Liu Z . Targeting the sonic hedgehog pathway in keratocystic odontogenic tumor. J Biol Chem. 2012; 287(32):27117-25. PMC: 3411054. DOI: 10.1074/jbc.M112.367680. View

13.

Kumamoto H, Ohki K, Ooya K . Expression of Sonic hedgehog (SHH) signaling molecules in ameloblastomas. J Oral Pathol Med. 2004; 33(3):185-90. DOI: 10.1111/j.0904-2512.2004.00070.x. View

14.

Alsaegh M, Miyashita H, Zhu S . Expression of human papillomavirus is correlated with Ki-67 and COX-2 expressions in keratocystic odontogenic tumor. Pathol Oncol Res. 2014; 21(1):65-71. DOI: 10.1007/s12253-014-9789-3. View

15.

ANNEROTH G, Hansen L . Variations in keratinizing odontogenic cysts and tumors. Oral Surg Oral Med Oral Pathol. 1982; 54(5):530-46. DOI: 10.1016/0030-4220(82)90192-x. View

16.

Gonzalez-Alva P, Tanaka A, Oku Y, Yoshizawa D, Itoh S, Sakashita H . Keratocystic odontogenic tumor: a retrospective study of 183 cases. J Oral Sci. 2008; 50(2):205-12. DOI: 10.2334/josnusd.50.205. View

17.

Jang H, Cho J, Yoon C, Kim H, Park J . Demonstration of Epstein-Barr virus in odontogenic and nonodontogenic tumors by the polymerase chain reaction (PCR). J Oral Pathol Med. 2001; 30(10):603-10. DOI: 10.1034/j.1600-0714.2001.301005.x. View

18.

Van Heerden W, van Rensburg E, Raubenheimer E, Venter E . Detection of human papillomavirus DNA in an ameloblastoma using the in situ hybridization technique. J Oral Pathol Med. 1993; 22(3):109-12. DOI: 10.1111/j.1600-0714.1993.tb01039.x. View

19.

Tarakji B, Baroudi K, Hanouneh S, Azzeghaiby S, Nassani M . Possible recurrence of keratocyst in nevoid basal cell carcinoma syndrome: A review of literature. Eur J Dent. 2014; 7(Suppl 1):S126-S134. PMC: 4054071. DOI: 10.4103/1305-7456.119090. View

20.

Gomes C, Oliveira C, Castro W, de Lacerda J, Gomez R . Clonal nature of odontogenic tumours. J Oral Pathol Med. 2009; 38(4):397-400. DOI: 10.1111/j.1600-0714.2008.00744.x. View